Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905639003> ?p ?o ?g. }
- W2905639003 endingPage "173" @default.
- W2905639003 startingPage "165" @default.
- W2905639003 abstract "This study aimed to investigate the antidiabetic activity of water-ethanol extract of green macroalgae Enteromorpha prolifera (EPW) and its flavonoid-rich fraction less than 3 kDa (EPW3) in type 2 diabetic mice induced by streptozotocin and a high-sucrose/high-fat diet. The major active compounds were identified using ultra-performance liquid chromatography coupled with quadrupole-time-of-flight-tandem mass spectrometry. Quantitative gene expression analysis of the insulin signaling pathway was performed. The effects of EPW3 on gut microflora in diabetic mice were analyzed by high-throughput 16S rRNA gene sequencing. The results showed EPW3 treatment decreased the fasting blood glucose, improved oral glucose tolerance, and protected against liver and kidney injury with reduced inflammation in diabetic mice. The active principle of EPW3 revealed hypoglycemic effect as indicated by activation of the IRS1/PI3K/AKT and inhibition of the JNK1/2 insulin pathway in liver. Furthermore, the treatment significantly enriched the abundance of Lachnospiraceae and Alisties, which were positive correlation of metabolic phenotypes. These findings indicated that EPW3 possessed great therapeutic potential as adjuvant therapy for type 2 diabetes." @default.
- W2905639003 created "2019-01-01" @default.
- W2905639003 creator A5009259955 @default.
- W2905639003 creator A5062685297 @default.
- W2905639003 creator A5067018911 @default.
- W2905639003 creator A5079023881 @default.
- W2905639003 creator A5085971155 @default.
- W2905639003 creator A5087699488 @default.
- W2905639003 creator A5089746504 @default.
- W2905639003 date "2018-12-19" @default.
- W2905639003 modified "2023-10-13" @default.
- W2905639003 title "Antidiabetic Potential of Green Seaweed<i>Enteromorpha prolifera</i>Flavonoids Regulating Insulin Signaling Pathway and Gut Microbiota in Type 2 Diabetic Mice" @default.
- W2905639003 cites W1536882007 @default.
- W2905639003 cites W1782966322 @default.
- W2905639003 cites W1971415551 @default.
- W2905639003 cites W1976517559 @default.
- W2905639003 cites W1979237890 @default.
- W2905639003 cites W1984430581 @default.
- W2905639003 cites W1987325365 @default.
- W2905639003 cites W1988925586 @default.
- W2905639003 cites W1989324173 @default.
- W2905639003 cites W2014887370 @default.
- W2905639003 cites W2022603507 @default.
- W2905639003 cites W2038018821 @default.
- W2905639003 cites W2060915038 @default.
- W2905639003 cites W2068737811 @default.
- W2905639003 cites W2070798627 @default.
- W2905639003 cites W2071841602 @default.
- W2905639003 cites W2073332363 @default.
- W2905639003 cites W2088833470 @default.
- W2905639003 cites W2094174828 @default.
- W2905639003 cites W2098945680 @default.
- W2905639003 cites W2103934714 @default.
- W2905639003 cites W2104578077 @default.
- W2905639003 cites W2104890139 @default.
- W2905639003 cites W2133582510 @default.
- W2905639003 cites W2152885278 @default.
- W2905639003 cites W2156472431 @default.
- W2905639003 cites W2266322142 @default.
- W2905639003 cites W2292575743 @default.
- W2905639003 cites W2340042701 @default.
- W2905639003 cites W2560288766 @default.
- W2905639003 cites W2592238217 @default.
- W2905639003 cites W2734680519 @default.
- W2905639003 cites W2773946960 @default.
- W2905639003 cites W2774396140 @default.
- W2905639003 cites W2779561740 @default.
- W2905639003 cites W2794095502 @default.
- W2905639003 cites W2902446450 @default.
- W2905639003 cites W73738779 @default.
- W2905639003 doi "https://doi.org/10.1111/1750-3841.14415" @default.
- W2905639003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30569533" @default.
- W2905639003 hasPublicationYear "2018" @default.
- W2905639003 type Work @default.
- W2905639003 sameAs 2905639003 @default.
- W2905639003 citedByCount "91" @default.
- W2905639003 countsByYear W29056390032018 @default.
- W2905639003 countsByYear W29056390032019 @default.
- W2905639003 countsByYear W29056390032020 @default.
- W2905639003 countsByYear W29056390032021 @default.
- W2905639003 countsByYear W29056390032022 @default.
- W2905639003 countsByYear W29056390032023 @default.
- W2905639003 crossrefType "journal-article" @default.
- W2905639003 hasAuthorship W2905639003A5009259955 @default.
- W2905639003 hasAuthorship W2905639003A5062685297 @default.
- W2905639003 hasAuthorship W2905639003A5067018911 @default.
- W2905639003 hasAuthorship W2905639003A5079023881 @default.
- W2905639003 hasAuthorship W2905639003A5085971155 @default.
- W2905639003 hasAuthorship W2905639003A5087699488 @default.
- W2905639003 hasAuthorship W2905639003A5089746504 @default.
- W2905639003 hasConcept C104317684 @default.
- W2905639003 hasConcept C112446052 @default.
- W2905639003 hasConcept C126322002 @default.
- W2905639003 hasConcept C134018914 @default.
- W2905639003 hasConcept C185592680 @default.
- W2905639003 hasConcept C2777180221 @default.
- W2905639003 hasConcept C2777391703 @default.
- W2905639003 hasConcept C2777695942 @default.
- W2905639003 hasConcept C2778004101 @default.
- W2905639003 hasConcept C2779054382 @default.
- W2905639003 hasConcept C2779280383 @default.
- W2905639003 hasConcept C2779306644 @default.
- W2905639003 hasConcept C2779704485 @default.
- W2905639003 hasConcept C42062724 @default.
- W2905639003 hasConcept C539455810 @default.
- W2905639003 hasConcept C55493867 @default.
- W2905639003 hasConcept C555293320 @default.
- W2905639003 hasConcept C62478195 @default.
- W2905639003 hasConcept C71924100 @default.
- W2905639003 hasConcept C86554907 @default.
- W2905639003 hasConcept C86803240 @default.
- W2905639003 hasConcept C98274493 @default.
- W2905639003 hasConceptScore W2905639003C104317684 @default.
- W2905639003 hasConceptScore W2905639003C112446052 @default.
- W2905639003 hasConceptScore W2905639003C126322002 @default.
- W2905639003 hasConceptScore W2905639003C134018914 @default.
- W2905639003 hasConceptScore W2905639003C185592680 @default.
- W2905639003 hasConceptScore W2905639003C2777180221 @default.