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- W2905711391 abstract "Introduction: The ongoing observational PROOF registry includes patients with a diagnosis of probable or definite IPF from 8 centres in Belgium and Luxembourg. Aims and objectives: This analysis summarised lung function change over 24 months in patients treated with pirfenidone in PROOF. Methods: Lung function data were collected at registry inclusion (baseline, Month 0) and 6, 12 and 24 months post-baseline. Results: During follow-up, 233/277 (84.1%) patients received pirfenidone for any duration of treatment (ever treated), with 87.1% treated without interruption until discontinuation or end of follow-up. A total of 44/277 (15.9%) patients did not receive pirfenidone. Mean %FVC at 0, 6, 12 and 24 months for patients ever treated with pirfenidone was 81.2% (n=205), 80.9% (n=163), 82.1% (n=146) and 78.3% (n=68), respectively. Mean %DLco at 0, 6, 12 and 24 months was 47.0% (n=197), 45.1% (n=155), 45.4% (n=136) and 45.0% (n=64), respectively. Absolute %FVC decline of ≥10% vs baseline was seen in 24/145 (16.6%), 25/131 (19.1%) and 18/58 (31.0%) patients at 6, 12 and 24 months, respectively, and 9/138 (6.5%), 8/122 (6.6%) and 14/57 (24.6%) had ≥15% absolute decline in %DLco vs baseline. Kaplan-Meier curves are presented in the Figure. Conclusions: Pulmonary function remained largely stable during 24 months of follow-up in the majority of ever-treated patients who received pirfenidone for any duration of treatment in PROOF." @default.
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- W2905711391 date "2018-09-15" @default.
- W2905711391 modified "2023-10-16" @default.
- W2905711391 title "Functional decline over time in patients with IPF treated with pirfenidone: the PROOF registry" @default.
- W2905711391 doi "https://doi.org/10.1183/13993003.congress-2018.pa2201" @default.
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