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- W2905769730 abstract "Introduction: Four patients with symptoms suggestive of OSA came to our attention. Diagnosis of GOLD 2B COPD dated two years, suggested starting LAMA therapy with glycopirronium. Aim of the study:in this case series was to highlight the complexity of treating patients with overlap syndrome Methods: Spirometry, six-minute-walking test (WT), modified Medical Research Council (mMRC)dyspnea scale and a full-night cardiorespiratory study were assessed. All patients were diagnosed OSAS and referred to continuous positive airway pressure (CPAP)therapy and daily oxygen therapy. After four months, all patients were re-evaluated. Results: an improvement of lung function at night was showed, although nocturnal desaturation analysis were still prolonged. Dyspnea on exertion still persisted.A increased Motley index, expressing dynamic hyperinflation persisted.GOLD 2017 suggest treating COPD patients with persisting symptoms with LABA plusLAMA combination. We switched our patients to the indacaterol/glycopirronium combination therapy. After Three months, patients were re-evaluated for lung function and overnight respiratory function was checked by nocturnal pulse oximetry testing during CPAP ventilation without oxygen addition. The results showed a significant improvement in the Motley index (reducing air trapping), WT and mMRC. Therapy was confirmed with suspension of oxygen administration during the ventilator support. Conclusions: In our report we maximized bronchodilation with the association indacaterol/glycopirronium, resolving persistent hyperinflation and being able to stop oxygen administration. Effective bronchodilation is a key strategy for improving exercise performance and night saturation." @default.
- W2905769730 created "2019-01-01" @default.
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- W2905769730 date "2018-09-15" @default.
- W2905769730 modified "2023-10-16" @default.
- W2905769730 title "Case series: efficacy and usefulness of double bronchodilation in patiens with Overlap syndrome (OSAS and COPD)." @default.
- W2905769730 doi "https://doi.org/10.1183/13993003.congress-2018.pa2506" @default.
- W2905769730 hasPublicationYear "2018" @default.
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