FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905886059> ?p ?o ?g. }

• W2905886059 endingPage "64" @default.
• W2905886059 startingPage "64" @default.
• W2905886059 abstract "This study has developed a reliable and precise high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of five phenolic acids and four flavonoid glycosides in rat plasma after a single intravenous administration of Kudiezi injection (KI). Chromatographic separation was carried out on an Ultimate®XB-C18 column (4.6 × 100 mm, 3.5 μm) using a gradient elution program with a mobile phase consisting of water containing 0.5% acetic acid and acetonitrile at a flow rate of 0.6 mL/min. Detection was performed on a triple-quadrupole tandem mass spectrometry using multiple reaction monitoring in negative electrospray ionization mode. The calibration curves of all analytes showed good linearity (R2 > 0.990). The results of selectivity, intra-day and inter-day precisions, extraction recoveries, matrix effects and stability were satisfactory. Pharmacokinetic parameters showed that luteolin-7-O-β-d-gentiobioside, luteolin-7-O-β-d-glucuronide, luteolin-7-O-β-d-glucoside and apigenin-7-O-β-d-glucuronide were eliminated quickly (0.07 h < t1/2 < 0.66 h), whereas 5-caffeoylquinic acid, caftaric acid, chlorogenic acid, 4-caffeoylquinic acid and caffeic acid were eliminated relatively slowly (2.22 h < t1/2 < 6.09 h) in rat blood. The pharmacokinetic results would be valuable to identify bioactive constituents, elucidate mechanisms of pharmacological actions or adverse drug reactions and guide the rational clinical use of KI." @default.
• W2905886059 created "2019-01-01" @default.
• W2905886059 creator A5002876333 @default.
• W2905886059 creator A5008554297 @default.
• W2905886059 creator A5056869471 @default.
• W2905886059 creator A5071518367 @default.
• W2905886059 creator A5074046260 @default.
• W2905886059 creator A5074524768 @default.
• W2905886059 date "2018-12-25" @default.
• W2905886059 modified "2023-09-26" @default.
• W2905886059 title "Simultaneous Determination of Five Phenolic Acids and Four Flavonoid Glycosides in Rat Plasma Using HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Intravenous Administration of Kudiezi Injection" @default.
• W2905886059 cites W1965774175 @default.
• W2905886059 cites W2015544289 @default.
• W2905886059 cites W2036547160 @default.
• W2905886059 cites W2044985046 @default.
• W2905886059 cites W2053273012 @default.
• W2905886059 cites W2054016435 @default.
• W2905886059 cites W2076456149 @default.
• W2905886059 cites W2086959952 @default.
• W2905886059 cites W2088361661 @default.
• W2905886059 cites W2095680342 @default.
• W2905886059 cites W2105813588 @default.
• W2905886059 cites W2116060738 @default.
• W2905886059 cites W2126904341 @default.
• W2905886059 cites W2139399563 @default.
• W2905886059 cites W2193956015 @default.
• W2905886059 cites W2371551808 @default.
• W2905886059 cites W2403616956 @default.
• W2905886059 cites W2414193843 @default.
• W2905886059 cites W2522324391 @default.
• W2905886059 cites W2557655838 @default.
• W2905886059 cites W2594371088 @default.
• W2905886059 cites W2766538169 @default.
• W2905886059 cites W2783506579 @default.
• W2905886059 cites W2788123114 @default.
• W2905886059 cites W2883099961 @default.
• W2905886059 cites W2884020741 @default.
• W2905886059 cites W2918592114 @default.
• W2905886059 doi "https://doi.org/10.3390/molecules24010064" @default.
• W2905886059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337671" @default.
• W2905886059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30585201" @default.
• W2905886059 hasPublicationYear "2018" @default.
• W2905886059 type Work @default.
• W2905886059 sameAs 2905886059 @default.
• W2905886059 citedByCount "6" @default.
• W2905886059 countsByYear W29058860592019 @default.
• W2905886059 countsByYear W29058860592020 @default.
• W2905886059 crossrefType "journal-article" @default.
• W2905886059 hasAuthorship W2905886059A5002876333 @default.
• W2905886059 hasAuthorship W2905886059A5008554297 @default.
• W2905886059 hasAuthorship W2905886059A5056869471 @default.
• W2905886059 hasAuthorship W2905886059A5071518367 @default.
• W2905886059 hasAuthorship W2905886059A5074046260 @default.
• W2905886059 hasAuthorship W2905886059A5074524768 @default.
• W2905886059 hasBestOaLocation W29058860591 @default.
• W2905886059 hasConcept C112705442 @default.
• W2905886059 hasConcept C162356407 @default.
• W2905886059 hasConcept C172493649 @default.
• W2905886059 hasConcept C178790620 @default.
• W2905886059 hasConcept C179998833 @default.
• W2905886059 hasConcept C185592680 @default.
• W2905886059 hasConcept C194671627 @default.
• W2905886059 hasConcept C2776080593 @default.
• W2905886059 hasConcept C2777477808 @default.
• W2905886059 hasConcept C2778004101 @default.
• W2905886059 hasConcept C2778224086 @default.
• W2905886059 hasConcept C2778778762 @default.
• W2905886059 hasConcept C2779054382 @default.
• W2905886059 hasConcept C2779186261 @default.
• W2905886059 hasConcept C2780117898 @default.
• W2905886059 hasConcept C31827203 @default.
• W2905886059 hasConcept C40684141 @default.
• W2905886059 hasConcept C43617362 @default.
• W2905886059 hasConcept C55493867 @default.
• W2905886059 hasConcept C71043704 @default.
• W2905886059 hasConcept C71240020 @default.
• W2905886059 hasConcept C71924100 @default.
• W2905886059 hasConcept C98274493 @default.
• W2905886059 hasConceptScore W2905886059C112705442 @default.
• W2905886059 hasConceptScore W2905886059C162356407 @default.
• W2905886059 hasConceptScore W2905886059C172493649 @default.
• W2905886059 hasConceptScore W2905886059C178790620 @default.
• W2905886059 hasConceptScore W2905886059C179998833 @default.
• W2905886059 hasConceptScore W2905886059C185592680 @default.
• W2905886059 hasConceptScore W2905886059C194671627 @default.
• W2905886059 hasConceptScore W2905886059C2776080593 @default.
• W2905886059 hasConceptScore W2905886059C2777477808 @default.
• W2905886059 hasConceptScore W2905886059C2778004101 @default.
• W2905886059 hasConceptScore W2905886059C2778224086 @default.
• W2905886059 hasConceptScore W2905886059C2778778762 @default.
• W2905886059 hasConceptScore W2905886059C2779054382 @default.
• W2905886059 hasConceptScore W2905886059C2779186261 @default.
• W2905886059 hasConceptScore W2905886059C2780117898 @default.
• W2905886059 hasConceptScore W2905886059C31827203 @default.
• W2905886059 hasConceptScore W2905886059C40684141 @default.
• W2905886059 hasConceptScore W2905886059C43617362 @default.
• W2905886059 hasConceptScore W2905886059C55493867 @default.
• W2905886059 hasConceptScore W2905886059C71043704 @default.

• next