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- W2905902743 endingPage "165358" @default.
- W2905902743 startingPage "165358" @default.
- W2905902743 abstract "The blood-brain barrier (BBB) is a component of the neurovascular unit formed by specialized brain microvascular endothelial cells (BMECs) surrounded by a specific basement membrane interacting with astrocytes, neurons, and pericytes. The BBB plays an essential function in the maintenance of brain homeostasis, by providing a physical and chemical barrier against pathogens and xenobiotics. Although the disruption of the BBB occurs with several neurological disorders, the scarcity of patient material source and lack of reliability of current in vitro models hindered our ability to model the BBB during such neurological conditions. The development of novel in vitro models based on patient-derived stem cells opened new venues in modeling the human BBB in vitro, by being more accurate than existing in vitro models, but also bringing such models closer to the in vivo setting. In addition, patient-derived models of the BBB opens the avenue to address the contribution of genetic factors commonly associated with certain neurological diseases on the BBB pathophysiology. This review provides a comprehensive understanding of the BBB, the current development of stem cell-based models in the field, the current challenges and limitations of such models." @default.
- W2905902743 created "2019-01-01" @default.
- W2905902743 creator A5002885033 @default.
- W2905902743 creator A5003962808 @default.
- W2905902743 creator A5047910951 @default.
- W2905902743 creator A5057900193 @default.
- W2905902743 date "2020-04-01" @default.
- W2905902743 modified "2023-10-05" @default.
- W2905902743 title "Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells" @default.
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