Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905935873> ?p ?o ?g. }
- W2905935873 endingPage "36" @default.
- W2905935873 startingPage "36" @default.
- W2905935873 abstract "Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes. This study aimed to evaluate the chronic effect of capsaicin administration on biomarkers of kidney injury in an experimental rat model of diabetes. Male Wistar rats were assigned to four groups: (1) healthy controls without diabetes (CON), (2) healthy controls plus capsaicin at 1 mg/kg/day (CON + CAPS), (3) experimental diabetes without capsaicin (DM), and (4) experimental diabetes plus capsaicin at 1 mg/kg/day (DM + CAPS). For each group, 24-h urine samples were collected to determine diuresis, albumin, cystatin C, β2 microglobulin, epidermal growth factor (EGF), alpha (1)-acid glycoprotein, and neutrophil gelatinase-associated lipocalin (NAG-L). Blood samples were drawn to measure fasting glucose. After 8 weeks, the CON + CAPS and DM + CAPS groups showed increased diuresis compared to the CON and DM groups, but the difference was significant only in the DM + CAPS group. The two-way ANOVA only showed a statistically significant effect of CAPS on the urinary EGF levels, as well as a tendency to have a significant effect in the urinary NAG-L levels. The EGF levels decreased in both CAPS-treated groups, but the change was only significant in the CON + CAPS group vs. CON group; and the NAG-L levels were lower in both CAPS-treated groups. These results show that capsaicin had a diuretic effect in healthy and diabetic rats; additionally, it increased the urinary EGF levels and tended to decrease the urinary NAG-L levels." @default.
- W2905935873 created "2019-01-01" @default.
- W2905935873 creator A5005265078 @default.
- W2905935873 creator A5046921211 @default.
- W2905935873 creator A5052638900 @default.
- W2905935873 creator A5065374489 @default.
- W2905935873 creator A5069834598 @default.
- W2905935873 creator A5070294958 @default.
- W2905935873 creator A5079076443 @default.
- W2905935873 creator A5080358968 @default.
- W2905935873 creator A5083685788 @default.
- W2905935873 creator A5085019385 @default.
- W2905935873 creator A5089362927 @default.
- W2905935873 date "2018-12-21" @default.
- W2905935873 modified "2023-10-16" @default.
- W2905935873 title "Effects of Chronic Administration of Capsaicin on Biomarkers of Kidney Injury in Male Wistar Rats with Experimental Diabetes" @default.
- W2905935873 cites W1584650885 @default.
- W2905935873 cites W1971955583 @default.
- W2905935873 cites W1974787420 @default.
- W2905935873 cites W1976030070 @default.
- W2905935873 cites W1979202154 @default.
- W2905935873 cites W1987525830 @default.
- W2905935873 cites W1988900895 @default.
- W2905935873 cites W1989967195 @default.
- W2905935873 cites W1990298982 @default.
- W2905935873 cites W1996017697 @default.
- W2905935873 cites W2009170554 @default.
- W2905935873 cites W2018735859 @default.
- W2905935873 cites W2025634113 @default.
- W2905935873 cites W2030534014 @default.
- W2905935873 cites W2030991171 @default.
- W2905935873 cites W2043010698 @default.
- W2905935873 cites W2056120307 @default.
- W2905935873 cites W2062179762 @default.
- W2905935873 cites W2078580988 @default.
- W2905935873 cites W2080576419 @default.
- W2905935873 cites W2081938413 @default.
- W2905935873 cites W2082404441 @default.
- W2905935873 cites W2083484726 @default.
- W2905935873 cites W2087307422 @default.
- W2905935873 cites W2092718776 @default.
- W2905935873 cites W2096748864 @default.
- W2905935873 cites W2099737510 @default.
- W2905935873 cites W2109278107 @default.
- W2905935873 cites W2116408316 @default.
- W2905935873 cites W2117343359 @default.
- W2905935873 cites W2200279038 @default.
- W2905935873 cites W2331165195 @default.
- W2905935873 cites W2338835625 @default.
- W2905935873 cites W2522334047 @default.
- W2905935873 cites W2605955340 @default.
- W2905935873 cites W2735466792 @default.
- W2905935873 cites W2765500255 @default.
- W2905935873 cites W2793800976 @default.
- W2905935873 cites W2793846954 @default.
- W2905935873 cites W2900053637 @default.
- W2905935873 cites W77525215 @default.
- W2905935873 doi "https://doi.org/10.3390/molecules24010036" @default.
- W2905935873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337195" @default.
- W2905935873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30583465" @default.
- W2905935873 hasPublicationYear "2018" @default.
- W2905935873 type Work @default.
- W2905935873 sameAs 2905935873 @default.
- W2905935873 citedByCount "9" @default.
- W2905935873 countsByYear W29059358732019 @default.
- W2905935873 countsByYear W29059358732020 @default.
- W2905935873 countsByYear W29059358732021 @default.
- W2905935873 countsByYear W29059358732022 @default.
- W2905935873 countsByYear W29059358732023 @default.
- W2905935873 crossrefType "journal-article" @default.
- W2905935873 hasAuthorship W2905935873A5005265078 @default.
- W2905935873 hasAuthorship W2905935873A5046921211 @default.
- W2905935873 hasAuthorship W2905935873A5052638900 @default.
- W2905935873 hasAuthorship W2905935873A5065374489 @default.
- W2905935873 hasAuthorship W2905935873A5069834598 @default.
- W2905935873 hasAuthorship W2905935873A5070294958 @default.
- W2905935873 hasAuthorship W2905935873A5079076443 @default.
- W2905935873 hasAuthorship W2905935873A5080358968 @default.
- W2905935873 hasAuthorship W2905935873A5083685788 @default.
- W2905935873 hasAuthorship W2905935873A5085019385 @default.
- W2905935873 hasAuthorship W2905935873A5089362927 @default.
- W2905935873 hasBestOaLocation W29059358731 @default.
- W2905935873 hasConcept C126322002 @default.
- W2905935873 hasConcept C134018914 @default.
- W2905935873 hasConcept C170493617 @default.
- W2905935873 hasConcept C2779547328 @default.
- W2905935873 hasConcept C2779918671 @default.
- W2905935873 hasConcept C2780051329 @default.
- W2905935873 hasConcept C2780091579 @default.
- W2905935873 hasConcept C555293320 @default.
- W2905935873 hasConcept C71924100 @default.
- W2905935873 hasConcept C77411442 @default.
- W2905935873 hasConceptScore W2905935873C126322002 @default.
- W2905935873 hasConceptScore W2905935873C134018914 @default.
- W2905935873 hasConceptScore W2905935873C170493617 @default.
- W2905935873 hasConceptScore W2905935873C2779547328 @default.
- W2905935873 hasConceptScore W2905935873C2779918671 @default.
- W2905935873 hasConceptScore W2905935873C2780051329 @default.