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- W2905936483 abstract "<b>Introduction:</b> BPD in infants born preterm is a risk factor for respiratory disease in adulthood. <b>Aims:</b> To evaluate lung function in young adults born preterm with and without a history of BPD compared to mild allergic asthmatics and healthy controls from the LUNAPRE cohort (clinicaltrials.gov/ct2/show/NCT03049202). <b>Methods:</b> Twenty-six individuals with a history of BPD, 23 age-matched individuals born preterm without diagnosis of BPD, 23 individuals with mild allergic asthma and 24 healthy controls were recruited in the study (mean age 19.9 years; range 18.2-23.8). All subjects were examined using dynamic spirometry, multiple breath wash-out, and diffusion capacity of the lung (DLCO). Symptoms were scored using St George9s Respiratory Questionnaire (SGRQ). <b>Results:</b> Young adults with a history of BPD had lower FEV<sub>1</sub> than preterm without BPD, (-0.94 vs. 0.28 z-scores; p ≤0.001); mild allergic asthmatics (0.14 z-scores, p ≤ 0.01) and healthy controls (0.78 z-scores, p≤0.001). The FEV<sub>1</sub>/FVC ratio was lower in the BPD-group compared to preterm without BPD (p ≤0.001), asthmatics (p=0.08) and healthy controls (p ≤0.001). The BPD-group had a higher lung clearance index than healthy controls (7.0 vs. 6.5, p≤0.001). Both preterm groups had lower DLCO compared to healthy controls (p≤0.001 for both). However, the SGRQ score was lower in the BPD-group compared to those with asthma (6.3 vs 16.5; p≤0.001). <b>Conclusions:</b> Adults with a history of BPD had obstructive lung function impairment including involvement of small airways. Despite more airway obstruction, the individuals in the BPD-group expressed less symptoms than those with mild asthma, highlighting the need for objective assessment of lung health in this group." @default.
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- W2905936483 date "2018-09-15" @default.
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- W2905936483 title "Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia (BPD)" @default.
- W2905936483 doi "https://doi.org/10.1183/13993003.congress-2018.pa1980" @default.
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