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• W2905961886 abstract "The piriform cortex (PCx) receives direct input from the olfactory bulb (OB) and is the brain's main station for odor recognition and memory. The transformation of the odor code from OB to PCx is profound: mitral and tufted cells in olfactory glomeruli respond to individual odorant molecules, whereas pyramidal neurons (PNs) in the PCx responds to multiple, apparently random combinations of activated glomeruli. How these ‘discontinuous’ receptive fields are formed from OB inputs remains unknown. Counter to the prevailing view that olfactory PNs sum their inputs passively, we show for the first time that NMDA spikes within individual dendrites can both amplify OB inputs and impose combination selectivity upon them, while their ability to compartmentalize voltage signals allows different dendrites to represent different odorant combinations. Thus, the 2-layer integrative behavior of olfactory PN dendrites provides a parsimonious account for the nonlinear remapping of the odor code from bulb to cortex." @default.
• W2905961886 created "2019-01-01" @default.
• W2905961886 creator A5009792159 @default.
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• W2905961886 date "2018-12-21" @default.
• W2905961886 modified "2023-10-17" @default.
• W2905961886 title "NMDA spikes mediate amplification of inputs in the rat piriform cortex" @default.
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• W2905961886 doi "https://doi.org/10.7554/elife.38446" @default.
• W2905961886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333441" @default.
• W2905961886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30575520" @default.
• W2905961886 hasPublicationYear "2018" @default.
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