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- W2905962805 abstract "Reasons for variation in pregnancy outcome with fetal gender in multifetal pregnancies remain incompletely elucidated. The a2 isoform of vacuolar adenosine triphosphatase (a2V) is expressed on the cell membrane of maternal lymphoid cells during gestation and regulates immune functions. The association between a2V levels on peripheral blood mononuclear cells (PBMCs), fetal gender in twin gestations and pregnancy outcome was assessed. PBMCs were isolated from 93 women with twin pregnancies – 27 with two male, 30 with two female and 36 with one male and one female fetus - and a2V determined in lysates by ELISA. Demographic and clinical data were subsequently obtained and correlations to a2V in relation to gender of the 1st and 2nd born twin were assessed by the Mann-Whitney and Spearman rank correlation tests. The mean a2V level was highest when both fetuses were male (2.0 ng/ml) and lowest when both were female (1.5 ng/ml) (p = 0.0184). The a2V concentration negatively correlated with gestational age at delivery (p = 0.0018) and with birthweight of the 1st (p = 0.0011) and 2nd (p = 0.0044) born fetus when both were female (p = 0.0018). There were no associations between a2V and these outcomes in male only or mixed twin pregnancies. a2V participation in pregnancy outcome only when a female fetus is present demonstrates that immune mechanisms during gestation differ depending on fetal gender ." @default.
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- W2905962805 date "2019-01-01" @default.
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- W2905962805 title "1002: Expression of the a2 isoform of vacuolar ATPase influences outcome only in female-female twin pregnancies" @default.
- W2905962805 doi "https://doi.org/10.1016/j.ajog.2018.11.1026" @default.
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