FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2905994751> ?p ?o ?g. }

• W2905994751 abstract "Abstract Aging is a complex process involving declines in various cellular and physical functionalities, including regenerative ability. Telomere maintenance is thought to be necessary for regeneration, and telomere attrition is one mechanism that contributes to aging. However, it is unclear if aging affects regeneration owing to deterioration of telomeric maintenance. We introduce Aeolosoma viride— a freshwater annelid with strong regenerative abilities—as a new model for studying the effects of aging on telomere functions and regeneration. We show that the anterior regenerative ability of A. viride declines with age. We characterized the A. viride telomere sequence as being composed of TTAGGG repeats and identifyied the telomerase gene Avi-tert . In adult A. viride , telomerase was constantly active and telomere lengths were similar among different body sections and stably maintained with age. Notably, we found that regeneration did not result in telomere shortening at regenerating sites. Moreover, transient up-regulation of Avi-tert expression and telomerase activity was observed at regenerating sites, which might promote telomere lengthening to counteract telomere erosion resulting from cell proliferation. Our study suggests that although aging affects A. viride regeneration independent of steady-state telomere length, timely regulation of telomerase functions is critical for the regeneration process in A. viride ." @default.
• W2905994751 created "2019-01-01" @default.
• W2905994751 creator A5043714307 @default.
• W2905994751 creator A5052856540 @default.
• W2905994751 creator A5070241168 @default.
• W2905994751 creator A5088494901 @default.
• W2905994751 date "2018-12-24" @default.
• W2905994751 modified "2023-10-12" @default.
• W2905994751 title "Telomere maintenance during anterior regeneration and aging in the freshwater annelid Aeolosoma viride" @default.
• W2905994751 cites W138052783 @default.
• W2905994751 cites W1503776092 @default.
• W2905994751 cites W1552502347 @default.
• W2905994751 cites W1600685357 @default.
• W2905994751 cites W16865729 @default.
• W2905994751 cites W1772653906 @default.
• W2905994751 cites W1834172848 @default.
• W2905994751 cites W1868176480 @default.
• W2905994751 cites W1921187749 @default.
• W2905994751 cites W1965343035 @default.
• W2905994751 cites W1965666620 @default.
• W2905994751 cites W1967155526 @default.
• W2905994751 cites W1974765744 @default.
• W2905994751 cites W1979628212 @default.
• W2905994751 cites W1990235009 @default.
• W2905994751 cites W1994600387 @default.
• W2905994751 cites W1995371868 @default.
• W2905994751 cites W1997811567 @default.
• W2905994751 cites W1999800789 @default.
• W2905994751 cites W2009357228 @default.
• W2905994751 cites W2011979100 @default.
• W2905994751 cites W2012003746 @default.
• W2905994751 cites W2019331028 @default.
• W2905994751 cites W2020595510 @default.
• W2905994751 cites W2026180657 @default.
• W2905994751 cites W2027581280 @default.
• W2905994751 cites W2028386203 @default.
• W2905994751 cites W2028921947 @default.
• W2905994751 cites W2035533979 @default.
• W2905994751 cites W2041534034 @default.
• W2905994751 cites W2049463405 @default.
• W2905994751 cites W2050345560 @default.
• W2905994751 cites W2051658606 @default.
• W2905994751 cites W2053352181 @default.
• W2905994751 cites W2054059225 @default.
• W2905994751 cites W2055035350 @default.
• W2905994751 cites W2081527689 @default.
• W2905994751 cites W2083541911 @default.
• W2905994751 cites W2095242811 @default.
• W2905994751 cites W2098700211 @default.
• W2905994751 cites W210795176 @default.
• W2905994751 cites W2109482972 @default.
• W2905994751 cites W2124013587 @default.
• W2905994751 cites W2124849774 @default.
• W2905994751 cites W2126525177 @default.
• W2905994751 cites W2127112863 @default.
• W2905994751 cites W2140251048 @default.
• W2905994751 cites W2149390987 @default.
• W2905994751 cites W2166029910 @default.
• W2905994751 cites W2168441241 @default.
• W2905994751 cites W2168495914 @default.
• W2905994751 cites W2179444197 @default.
• W2905994751 cites W2340395074 @default.
• W2905994751 cites W4210461863 @default.
• W2905994751 cites W73526163 @default.
• W2905994751 doi "https://doi.org/10.1038/s41598-018-36396-y" @default.
• W2905994751 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305377" @default.
• W2905994751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30584242" @default.
• W2905994751 hasPublicationYear "2018" @default.
• W2905994751 type Work @default.
• W2905994751 sameAs 2905994751 @default.
• W2905994751 citedByCount "7" @default.
• W2905994751 countsByYear W29059947512020 @default.
• W2905994751 countsByYear W29059947512022 @default.
• W2905994751 countsByYear W29059947512023 @default.
• W2905994751 crossrefType "journal-article" @default.
• W2905994751 hasAuthorship W2905994751A5043714307 @default.
• W2905994751 hasAuthorship W2905994751A5052856540 @default.
• W2905994751 hasAuthorship W2905994751A5070241168 @default.
• W2905994751 hasAuthorship W2905994751A5088494901 @default.
• W2905994751 hasBestOaLocation W29059947511 @default.
• W2905994751 hasConcept C104317684 @default.
• W2905994751 hasConcept C105702510 @default.
• W2905994751 hasConcept C1491633281 @default.
• W2905994751 hasConcept C171056886 @default.
• W2905994751 hasConcept C177336024 @default.
• W2905994751 hasConcept C2776759703 @default.
• W2905994751 hasConcept C2777343278 @default.
• W2905994751 hasConcept C522857546 @default.
• W2905994751 hasConcept C54355233 @default.
• W2905994751 hasConcept C85813293 @default.
• W2905994751 hasConcept C86803240 @default.
• W2905994751 hasConcept C94581717 @default.
• W2905994751 hasConcept C95444343 @default.
• W2905994751 hasConceptScore W2905994751C104317684 @default.
• W2905994751 hasConceptScore W2905994751C105702510 @default.
• W2905994751 hasConceptScore W2905994751C1491633281 @default.
• W2905994751 hasConceptScore W2905994751C171056886 @default.
• W2905994751 hasConceptScore W2905994751C177336024 @default.
• W2905994751 hasConceptScore W2905994751C2776759703 @default.
• W2905994751 hasConceptScore W2905994751C2777343278 @default.

• next