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- W2905995736 abstract "Numerous target agents promising longer survival with fewer adverse events have recently been approved for the treatment of NSCLC and are associated with high drug prices. Using the reference years 2009 and 2013, we aimed to detect changes in the therapy with targeted agents and resulting costs, in the year after the initial diagnosis. We analyzed German health insurance claims of 6,822 and 7,414 patients with advanced lung cancer diagnosed in 2009 or 2013, respectively. We used procedural and ATC codes to identify therapy with targeted agents, and claims for in- and outpatient visits and for drug prescriptions to calculate daily therapy costs. 2009 costs were inflated and compared with 2013 costs using generalized linear models with gamma distribution, adjusted by age, gender, comorbidities and area of residence. The proportion of patients receiving targeted therapies remained stable at around 11%. There was an increase in the usage of bevacizumab (1.5% to 2.6%) and gefitinib (0.6% to 1.3%), whereas usage decreased for cetuximab (0.5% to 0.1%) and erlotinib (8.2% to 5.3%). Crizotinib and afatinib were approved after 2009 only and received by 0.4% and 0.1% of patients in 2013, respectively. Daily costs were 4% (p Therapy in lung cancer is changing due to new targeted therapies. Costs are increasing especially for the drugs themselves. However, usage is limited to only around 11% of patients so far." @default.
- W2905995736 created "2019-01-01" @default.
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- W2905995736 date "2018-09-15" @default.
- W2905995736 modified "2023-09-23" @default.
- W2905995736 title "Changes in targeted therapy and costs in NSCLC between 2009 and 2013" @default.
- W2905995736 doi "https://doi.org/10.1183/13993003.congress-2018.pa2216" @default.
- W2905995736 hasPublicationYear "2018" @default.
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