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- W2906004949 abstract "We previously reported persistence in the overall MS population1 and the current study examines the impact of age on persistence for all reimbursed DMTs for RRMS in Australia. This study used The Pharmaceutical Benefits Scheme 10% sample (supplied by Australia government). Eligible patients received a script for a reimbursed DMT for RRMS between September 2011 and February 2016. Patients were classified into five age-groups (ages 18-30; 31-40; 41-50; 51-60; 61+) and were defined as persistent if their DMT script was filled within 4 months. Persistence was derived using the Kaplan-Meier method and the relative rate of persistence was compared using hazard ratios (HR). A total of 1866 non-unique treatment episodes were eligible for the study. Overall the median persistence to therapy was 30 months with 68% of patients remaining on therapy for 12 months. Patients aged 18-30 had the shortest persistence (18 months) and a 44% increased risk of discontinuation when compared to the ‘all ages’ cohort (HR 1.44 (95%CI: 1.22-1.72) and was identified as a ‘high-risk’ group. For all other age-groups, when compared to Product Average, HR’s were between 1.08 and 0.92. For patients aged 18-30 there was statistically significant lower persistence (median 9 months) on injectable therapy (glatiramer acetate, interferon beta-1a, interferon beta-1b) when compared to the persistent product average (median 18 months) with a hazard ratio of 1.95 (95% CI: 1.35-2.81). Patients on non-injectables (dimethyl fumarate, fingolimod, natalizumab, teriflunomide; n=188) had a median persistence of 24 months (HR 0.81(95% CI: 0.65-1.02 p=0.07). Further examination of individual drugs will depend upon availability of 100% PBS data. In this analysis of PBS sample data, patients aged 18-30 were least persistent to treatment when compared to the product average. The persistence on injectable therapy was significant lower compared to all drugs in this high-risk group." @default.
- W2906004949 created "2019-01-01" @default.
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- W2906004949 date "2018-10-01" @default.
- W2906004949 modified "2023-09-26" @default.
- W2906004949 title "PND13 - REAL WORLD EVIDENCE (RWE) ON IMPACT OF AGE ON LONG-TERM PERSISTENCE TO DISEASE MODIFYING THERAPIES (DMTS) IN RELAPSING-REMITTING MULTIPLE SCLEROSIS (RRMS) IN AUSTRALIA" @default.
- W2906004949 doi "https://doi.org/10.1016/j.jval.2018.09.1980" @default.
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