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- W2906010352 endingPage "354" @default.
- W2906010352 startingPage "340" @default.
- W2906010352 abstract "Systemic lupus erythematosus (SLE) is characterized by the production of multiple autoantibodies, some of which, including anti-dsDNA, anti-Smith, and VH4-34–encoded antibodies, are highly specific for this disease, whereas others (antiribonucleoprotein [RNP] and anti-Ro among others) are shared with other autoimmune diseases. Lupus autoantibodies also differ in terms of clinical associations and stability throughout the disease course. It is accepted that the generation of pathogenic autoantibodies requires defective B-cell tolerance ultimately leading to the expansion of autoreactive plasma cells (PCs). However, the genetic basis of lupus autoantibodies and their structural determinants remain poorly understood. Similarly, the role of different B-cell compartments (innate B cells, germinal center-derived B cells, and extrafollicular B cells) in the generation of autoreactive PCs endowed with different longevity and their participation in the production of distinct types of lupus autoantibodies remains to be elucidated. In this chapter, we will review extant knowledge of the molecular and genetic basis of lupus autoantibodies and discuss information relevant to understanding their cellular sources." @default.
- W2906010352 created "2019-01-01" @default.
- W2906010352 creator A5045495959 @default.
- W2906010352 creator A5048259074 @default.
- W2906010352 creator A5081582773 @default.
- W2906010352 date "2019-01-01" @default.
- W2906010352 modified "2023-10-17" @default.
- W2906010352 title "Structure and Derivation of Autoantibodies" @default.
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