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- W2906012115 abstract "Introduction: REFIPIMAD registry was created to known the epidemiological and clinical characteristics of idiopathic pulmonary fibrosis patients (IPF) in the community of Madrid (Spain). Aim: To describe the clinical, safety and tolerability characteristics of IPF patients included in REFIPIMAD registry and treated with Nintedanib in real life. Results: 44 patients are described, mean age 66 ±7.9 years (range 79-44), 35 (79%) were men, 30 (68%) were smokers or ex-smokers with an average of 32 paq/year. Comorbidity: Previous AMI in 4 patients, 6 diabetes mellitus, 3 peptic ulcer and 1 peripheral arteriopathy. The HRCT radiological pattern was UIP in 28 (64%), possible UIP in 14 (32%) and 9 (20%) had associated emphysema. Surgical lung biopsy was performed in 14 patients. Pulmonary function tests at the beginning of the treatment were (mean ± SD [range]) FVC 83% ± 18 (55%-122%) of the predicted value, DLCO 59% ± 17 (34%-103%) of the predicted value, six-minute walk distance 479 ± 98 (98-479) metres, initial SpO2 94 ± 1.7, final SpO2 87 ± 4.4. The average treatment time was 10.3 ± 11.3 months (range 44.93-0.43); 20 patients (50%) suffer some side effects: diarrhea 15 (36%) , weight loss 9 (21%), other gastro-intestinal alterations 15 (12%), liver disorders 5 (12%), hiporexia 6 (14%) and other effects 3 (4%). The treatment was definitively withdrawn in 4 patients (16%) who switched to pirfenidone and other 3 with pirfenidone switched to Nintedanib. Pulmonary function test follow-up are available in 16 patients who showed stability. Conclusion: Preliminary data of Nintedanib treatment in real life show a good safety profile and data consistent with those published in clinical trials." @default.
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- W2906012115 date "2018-09-15" @default.
- W2906012115 modified "2023-10-14" @default.
- W2906012115 title "Experience of patients treated with nintedanib in the Community of Madrid. REFIPIMAD Registry" @default.
- W2906012115 doi "https://doi.org/10.1183/13993003.congress-2018.pa4794" @default.
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