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- W2906067029 abstract "Volatile organic compounds (VOCs) in breath can reflect host and pathogen metabolism and might be used to diagnose pneumonia (Oort J Breath Res 2018). We hypothesized that rats with Streptococcus pneumoniae (SP) or Pseudomonas aeruginosa (PA) pneumonia can be discriminated from uninfected controls by gas-chromatography mass-spectrometry (GC-MS) of exhaled breath. Male adult rats (N = 50) received an intra-tracheal inoculation of 1) 200µL saline, 2) 1x107 colony forming units (cfu) of SP or 3) 1x107 cfu of PA. 24 hours later the rats were anaesthetized, tracheotomized and mechanically ventilated. Exhaled breath was analyzed via GC-MS. Area under the receiver operating characteristic curve (AUROCC) was calculated after leave-one-out cross-validation of sparse partial least squares discriminant analysis (sPLS-DA). The AUROCC was 0.85 (95%-CI: 0.73-0.96) for infected vs. non-infected animals. The AUROCC was 0.98 (95%-CI: 0.94-1) for SP vs. PA, 0.92 (95%-CI: 0.83-1) for SP vs. controls and 0.97 (95%-CI: 0.92-1) for PA vs. controls. Exhaled breath analysis discriminated with good accuracy between respiratory infection and no infection, but with much better accuracy between the specific pathogens. Clinical studies should focus more on the discrimination between specific pathogens, instead of the general presence of respiratory infection." @default.
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- W2906067029 date "2018-09-15" @default.
- W2906067029 modified "2023-09-26" @default.
- W2906067029 title "Exhaled breath analysis for the detection of Streptococcus pneumoniae and Pseudomonas aeruginosa lung infections using gas chromatography – mass spectrometry: a rat model study." @default.
- W2906067029 doi "https://doi.org/10.1183/13993003.congress-2018.pa2659" @default.
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