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- W2906075420 abstract "Objective: In this study, we aimed to determine the transcriptomes of myometrial tissues from pregnant women at term who were in labor vs. women at term who were not in labor to elucidate genes associated with spontaneous labor. Study Design: Using human myometrial tissues from pregnant women at term who were not in labor (TNIL; n=8), and women at term who were in labor (TIL; n=6), we performed deep RNA-sequencing using the DESeq platform at a total of 30-40 million reads per sample. Results: Principal component analysis (PCA) indicated the TNIL and TIL transcriptomes can be distinguished as two distinct clusters. Over 44,000 genes were differentially expressed between TIL and TNIL samples. A total of 23,330 genes (51%) were upregulated and 21,770 (49%) downregulated. Pathway analysis revealed that muscle contraction, ion transport, and oxytocin signaling pathways are activated in TIL myometrial tissues compared to TNIL myometrial tissues. Conversely, compared to TNIL myometrium tissues, the pathways downregulated in TIL myometrial tissues included those involved in RNA/protein stability, the NOD-like receptor protein 3 (NLRP3) inflammasome, and the regulation of circadian rhythm (Figure 1). Conclusion: Transcriptomes of myometrium from women at term who are in labor are distinct from women at term who are not in labor; this difference may be essential to understanding the initiation of spontaneous labor. Understanding the various pathways enriched in both up and downregulated genes in women in labor at term could prove useful in identifying the gene signatures that can be used as a basis for understanding the etiology of and targets for the prevention of preterm labor and birth." @default.
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- W2906075420 date "2019-01-01" @default.
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- W2906075420 title "668: The human myometrial transcriptome uncovers pathways associated with spontaneous labor" @default.
- W2906075420 doi "https://doi.org/10.1016/j.ajog.2018.11.690" @default.
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