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• W2906077174 abstract "Summary Preeclampsia ( PE ) is a leading cause of maternal and perinatal death. Accumulated evidence suggests that many long non‐coding RNA s (lnc RNA s) are abnormally expressed in placentas from PE patients, and they may play functional roles in the development of PE . The present study aimed to investigate the functional role TUG 1 in PE and explore the potential molecular mechanisms. Clinically, the expression of TUG 1 in placental tissues from PE and normal controls was determined. In vitro, human trophoblast HTR ‐8/ SV neo and JAR cells were employed for loss or gain‐of‐function assays. Our results demonstrate that TUG 1 was downregulated in PE placental tissues compared with normal controls. Moreover, downregulation of TUG 1 inhibited the migration and invasion of trophoblast‐like cells. Bioinformatics analysis and functional assays showed that TUG 1 interacted with miR‐204‐5p and negatively regulated the expression and function of miR‐204‐5p in trophoblast cells. Furthermore, TUG 1‐mediated migration and invasion of trophoblast cells was regulated by miR‐204‐5p. Together, our results suggested that TUG 1 regulates trophoblast migration and invasion partly through sponging miR‐204‐5p, and the TUG 1/miR‐204‐5p axis could be a potential therapeutic target for the treatment of PE ." @default.
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• W2906077174 date "2019-02-19" @default.
• W2906077174 modified "2023-09-27" @default.
• W2906077174 title "Long non‐coding<scp>RNA TUG</scp>1 regulates the migration and invasion of trophoblast‐like cells through sponging miR‐204‐5p" @default.
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• W2906077174 doi "https://doi.org/10.1111/1440-1681.13058" @default.
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