FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906088893> ?p ?o ?g. }

• W2906088893 endingPage "204173141881750" @default.
• W2906088893 startingPage "204173141881750" @default.
• W2906088893 abstract "Concentrated growth factor, a novel autologous plasma extract, contained various growth factors which promoted tissue regeneration. In this study, we aimed to investigate the biological effects of concentrated growth factor on human dental pulp stem cells. The microstructure and biocompatibility of concentrated growth factor scaffolds were evaluated by scanning electron microscopy. Cell proliferation and migration, odontoblastic and endothelial cell differentiation potential were assessed after exposing dental pulp stem cells to different concentrations (5%, 10%, 20%, 50%, or 80%) of concentrated growth factor extracts. The results revealed that concentrated growth factor scaffolds possessed porous fibrin network with platelets and leukocytes, and showed great biocompatibility with dental pulp stem cells. Higher cell proliferation rates were detected in the concentrated growth factor–treated groups in a dose-dependent manner. Interestingly, in comparison to the controls, the low doses (<50%) of concentrated growth factor increased cell migration, alkaline phosphatase activity, and mineralized tissue deposition, while the cells treated in high doses (50% or 80%) showed no significant difference. After stimulating cell differentiation, the expression levels of dentin matrix protein-1, dentin sialophosphoprotein, vascular endothelial growth factor receptor-2 and cluster of differentiation 31 were significantly upregulated in concentrated growth factor–supplemented groups than those of the controls. Furthermore, the dental pulp stem cell–derived endothelial cells co-induced by 5% concentrated growth factor and vascular endothelial growth factor formed the most amount of mature tube-like structures on Matrigel among all groups, but the high-dosage concentrated growth factor exhibited no or inhibitory effect on cell differentiation. In general, our findings confirmed that concentrated growth factor promoted cell proliferation, migration, and the dental pulp stem cell–mediated dentinogenesis and angiogenesis process, by which it might act as a growth factor–loaded scaffold to facilitate dentin–pulp complex healing." @default.
• W2906088893 created "2019-01-01" @default.
• W2906088893 creator A5021344756 @default.
• W2906088893 creator A5028166621 @default.
• W2906088893 creator A5029983714 @default.
• W2906088893 creator A5036834339 @default.
• W2906088893 creator A5049271159 @default.
• W2906088893 creator A5058483685 @default.
• W2906088893 date "2018-01-01" @default.
• W2906088893 modified "2023-09-30" @default.
• W2906088893 title "Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro" @default.
• W2906088893 cites W1905855640 @default.
• W2906088893 cites W1949832432 @default.
• W2906088893 cites W1963907322 @default.
• W2906088893 cites W1966079910 @default.
• W2906088893 cites W1987870064 @default.
• W2906088893 cites W2000733039 @default.
• W2906088893 cites W2015186671 @default.
• W2906088893 cites W2042130427 @default.
• W2906088893 cites W2075540043 @default.
• W2906088893 cites W2114429558 @default.
• W2906088893 cites W2139776494 @default.
• W2906088893 cites W2154688513 @default.
• W2906088893 cites W2175053422 @default.
• W2906088893 cites W2214755608 @default.
• W2906088893 cites W2295906683 @default.
• W2906088893 cites W2345735458 @default.
• W2906088893 cites W2400516753 @default.
• W2906088893 cites W2411267795 @default.
• W2906088893 cites W2412843507 @default.
• W2906088893 cites W2511630974 @default.
• W2906088893 cites W2511643530 @default.
• W2906088893 cites W2518895572 @default.
• W2906088893 cites W2591304528 @default.
• W2906088893 cites W2603825787 @default.
• W2906088893 cites W2764001195 @default.
• W2906088893 cites W2767026035 @default.
• W2906088893 cites W2800890057 @default.
• W2906088893 cites W2802015575 @default.
• W2906088893 cites W2802248292 @default.
• W2906088893 cites W2808439730 @default.
• W2906088893 cites W2897323151 @default.
• W2906088893 doi "https://doi.org/10.1177/2041731418817505" @default.
• W2906088893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6304703" @default.
• W2906088893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30622693" @default.
• W2906088893 hasPublicationYear "2018" @default.
• W2906088893 type Work @default.
• W2906088893 sameAs 2906088893 @default.
• W2906088893 citedByCount "49" @default.
• W2906088893 countsByYear W29060888932019 @default.
• W2906088893 countsByYear W29060888932020 @default.
• W2906088893 countsByYear W29060888932021 @default.
• W2906088893 countsByYear W29060888932022 @default.
• W2906088893 countsByYear W29060888932023 @default.
• W2906088893 crossrefType "journal-article" @default.
• W2906088893 hasAuthorship W2906088893A5021344756 @default.
• W2906088893 hasAuthorship W2906088893A5028166621 @default.
• W2906088893 hasAuthorship W2906088893A5029983714 @default.
• W2906088893 hasAuthorship W2906088893A5036834339 @default.
• W2906088893 hasAuthorship W2906088893A5049271159 @default.
• W2906088893 hasAuthorship W2906088893A5058483685 @default.
• W2906088893 hasBestOaLocation W29060888931 @default.
• W2906088893 hasConcept C1491633281 @default.
• W2906088893 hasConcept C160160445 @default.
• W2906088893 hasConcept C167734588 @default.
• W2906088893 hasConcept C170493617 @default.
• W2906088893 hasConcept C178790620 @default.
• W2906088893 hasConcept C181199279 @default.
• W2906088893 hasConcept C185592680 @default.
• W2906088893 hasConcept C203014093 @default.
• W2906088893 hasConcept C2775960820 @default.
• W2906088893 hasConcept C2777025900 @default.
• W2906088893 hasConcept C2777230088 @default.
• W2906088893 hasConcept C2777400515 @default.
• W2906088893 hasConcept C2778608917 @default.
• W2906088893 hasConcept C2779203663 @default.
• W2906088893 hasConcept C28328180 @default.
• W2906088893 hasConcept C502942594 @default.
• W2906088893 hasConcept C55493867 @default.
• W2906088893 hasConcept C62112901 @default.
• W2906088893 hasConcept C86803240 @default.
• W2906088893 hasConcept C95444343 @default.
• W2906088893 hasConceptScore W2906088893C1491633281 @default.
• W2906088893 hasConceptScore W2906088893C160160445 @default.
• W2906088893 hasConceptScore W2906088893C167734588 @default.
• W2906088893 hasConceptScore W2906088893C170493617 @default.
• W2906088893 hasConceptScore W2906088893C178790620 @default.
• W2906088893 hasConceptScore W2906088893C181199279 @default.
• W2906088893 hasConceptScore W2906088893C185592680 @default.
• W2906088893 hasConceptScore W2906088893C203014093 @default.
• W2906088893 hasConceptScore W2906088893C2775960820 @default.
• W2906088893 hasConceptScore W2906088893C2777025900 @default.
• W2906088893 hasConceptScore W2906088893C2777230088 @default.
• W2906088893 hasConceptScore W2906088893C2777400515 @default.
• W2906088893 hasConceptScore W2906088893C2778608917 @default.
• W2906088893 hasConceptScore W2906088893C2779203663 @default.
• W2906088893 hasConceptScore W2906088893C28328180 @default.
• W2906088893 hasConceptScore W2906088893C502942594 @default.

• next