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- W2906152022 abstract "<b>Background:</b> Atopic bronchial asthma (ABA) is the most frequent multifactorial disease of respiratory organs in children; its development is dependent on many environmental and genetic factors. Cytokine genes are crucially important for ABA pathogenesis as they encode proteins participating in immune response and inflammation. <b>Aims and objectives:</b> The distribution of genotypes of polymorphic genes IL4 (rs2070874, rs2243250) and IL5 (rs2069812) was studied in order to study the formation of predisposition to atopic bronchial asthma (ABA) of varying severity in children of European origin residing in the Krasnoyarsk Territory. <b>Methods:</b> We analyzed cytokines gene polymorphisms (IL4, IL5) in asthmatic children with different disease severity (mild asthma (n=72), moderate asthma (n=67), and severe asthma (n=71)) and population sample (n=136). The analysis was performed on DNA isolated from peripheral blood by a standard method with a sorbent. Genotyping was carried out by PCR and RFLP-analysis with electrophoretic detection in an agarose gel. The frequencies of genotypes corresponding to Caucasoid populations were determined. <b>Results:</b> It was shown that the CT genotype (C-33T IL4) prevailed in the ABA group (47.89%) compared with the control group (30.88%) (p=0.09). The allelic variant T-33 shown an association with mild ABA (OR 1.48 (0.94-2.35), p=0.09). <b>Conclusions:</b> Further study will reveal clear genetic markers among the immune response genes for the purpose of personalized diagnosis of the risk of developing ABA and the treatment of its severe forms." @default.
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- W2906152022 date "2018-09-15" @default.
- W2906152022 modified "2023-10-11" @default.
- W2906152022 title "Polymorphism of genes (IL4, IL5) as genetic predisposition to asthma in children" @default.
- W2906152022 doi "https://doi.org/10.1183/13993003.congress-2018.pa4462" @default.
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