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- W2906156789 abstract "The 2017 American College of Cardiology/American Heart Association (ACC/AHA) High Blood Pressure Guidelines lowered high blood pressure threshold for recommending earlier intervention to prevent cardiovascular disease (CVD). This study estimated the impact of initiating timely anti-hypertensive medications on the risk of clinical events (AMI, stroke and death) and on healthcare costs in patients potentially qualifying for anti-hypertensive treatment under the 2017 guidelines. High-risk patients qualifying for anti-hypertensive medications under the 2017 guidelines were identified using Optum data [2007-2016]. Patients with a diagnosis of elevated blood pressure were assumed eligible for hypertension treatment under new guidelines. Patients were further designated into two treatment groups depending on whether patients initiated treatment before experiencing a cardiovascular event or not. Comorbidities including diabetes, chronic kidney disease and obesity as known risk factors of CVD were specially interpreted in the analysis. The impact of timely anti-hypertensive medications on CVD risk and on healthcare costs were estimated using Cox proportional hazards models and generalized linear models [GLM], respectively. 918,110 patients met eligibility requirements and all other study inclusion criteria. 66% of potential treatment target patients initiated treatment during 2007-2016. Initiating timely anti-hypertensive treatment decreased the likelihood of having AMI by 59%, stroke by 60% and death by 10%. Patients with elevated blood pressure still experienced reduced risk of stroke once they initiated medications. Treatment could lower the risk of AMI or stroke across each comorbidity categories (diabetes, chronic renal disease and obesity) and show a significant effect on lowering all-cause health care costs in the first post-index year. Initiating timely anti-hypertensive medications was associated with reduced risk of AMI, stroke and death for all hypertensive patients identified in new guidelines. Patients with elevated blood pressure, the primary source of any expanded eligible population under new guidelines, experienced lower risk of stroke once treated." @default.
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- W2906156789 date "2018-10-01" @default.
- W2906156789 modified "2023-09-30" @default.
- W2906156789 title "PCV131 - IMPACT OF TIMELY INITIATION OF ANTIHYPERTENSIVE MEDICATIONS FOR PATIENTS WITH HYPERTENSION OR ELEVATED BLOOD PRESSURE" @default.
- W2906156789 doi "https://doi.org/10.1016/j.jval.2018.09.676" @default.
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