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- W2906175094 abstract "Preeclampsia is apregnancy complication; early identification with increased risk is one of thekey goals in obstetrics. In a nested case control study, serum uric acid andcalcium measured in first and second trimesters of pregnancy were correlatedwith Xanthine oxidase (XO) activity, mean arterial pressure (MAP) and fetalbirth weight. The mean ± SD of uric acid (2.01 ± 0.85,4.8 ± 1.93), calcium (10.88 ± 1.97, 9.72 ± 2.04), MAP (84.32 ± 6.71, 78.40 ± 8.53) and XO activity (11.96 ± 1.91,14.05 ± 3.09) of the study group(n=86) were observed in the first and second trimesters respectively. Firsttrimester normotensive group (n=79) and preeclampsia cases (n = 7), showed a mean ± SD of uric acid (1.93 ± 0.80, 2.9 ± 0.88), Calcium (10.92 ± 1.9, 10.6 ± 1.72),MAP (84.19 ± 6.75, 85.71 ± 6.58) XO activity (11.82 ± 1.83,13.57 ± 2.21). In the secondtrimester, normotensive group and preeclampsia cases showed a mean ± SD uric acid (4.6 ± 1.75, 7.3 ± 2.19), Calcium (9.4 ± 1.85, 12.9 ± 1.04),MAP (76.41 ± 5.41, 100.95 ± 2.52) and XO activity (13.37 ± 1.93,21.70 ± 3.50). Statisticalanalysis revealed a non-significant positive correlation in first trimesterbetween uric acid and MAP (r = +0.116, p = 0.288), negative correlationsbetween uric acid and fetal birth weight (r = -0.118, 0.279) and between calcium and MAP (r = -0.288,p = 0.007). In the second trimester, significant positive correlations wereobserved between uric acid (r = +0.246, p =0.022), calcium (r = +0.326, p = 0.007) with MAP along with a significant negativecorrelation between uric acid (r = -0.641, p = 0.000), calcium (r = -0.316, p = 0.003), Proteinuria(r = -0.514, p = 0.000) withfetal birth weight. The screening of first and second trimesters XO activity,uric acid, calcium and MAP during pregnancy is beneficial in identifying womenlikely to develop preeclampsia with poor fetal outcome." @default.
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- W2906175094 date "2018-01-01" @default.
- W2906175094 modified "2023-10-01" @default.
- W2906175094 title "Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study" @default.
- W2906175094 doi "https://doi.org/10.4236/ojog.2018.814154" @default.
- W2906175094 hasPublicationYear "2018" @default.
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