FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906248623> ?p ?o ?g. }

• W2906248623 abstract "Among Alzheimer's disease (AD) patients, it is very common to develop behavioral and psychological symptoms of dementia (BPSD), which has a close relation to the excess morbidity and mortality, greater healthcare use, earlier institutionalization, and caregiver burden. With evaluation of AD patients, the present study mainly aims to investigate whether citalopram would be efficient for BPSD, and examines citalopram's effects on cognitive function, caregiver distress, safety and tolerability. Eighty patients diagnosed with moderate AD and clinically significant BPSD from April 2015 to January 2016 were enrolled in this study. Patients randomly received memantine plus either citalopram (n=40, study group) or placebo (n=40, control group) in a 12-week period. The target dose of memantine was 20 mg/day. The dose of citalopram was 10 mg/day in the beginning with planned titration to 30 mg/day over 2 weeks on the basis of response and tolerability. Blood routine, urine routine, biochemical tests, electrocardiogram and electroencephalogram were carried out for each patient every month routinely to check the change induced by using medication. Treatment Emergent Symptom Scale (TESS) was used to measure untoward effects every 2 weeks. All of the agitation/aggression, irritability/lability, night-time behavioral disturbances, caregiver distress and Neuropsychiatric Inventory (NPI) total scores after treatment were found to be dramatically lower than those before treatment in both groups. Apathy, dysphoria and anxiety received lower scores in participants who received memantine combined with citalopram, compared to those before treatment. QTc interval prolongation was observed in 2 patients who were treated with 30 mg/day citalopramin. In conclusion, memantine combined with citalopram can more effectively improve the cognitive function, and reduce behavioral and psychological symptoms in patients with moderate AD. Cardiac adverse effects of citalopram are not common when the dose is <30 mg/day, which does not limit its practical application. Thus, citalopram has shown potential efficacy in adjunctive therapy of AD patients with BPSD." @default.
• W2906248623 created "2019-01-01" @default.
• W2906248623 creator A5014045791 @default.
• W2906248623 creator A5034911944 @default.
• W2906248623 creator A5039281538 @default.
• W2906248623 creator A5049441085 @default.
• W2906248623 creator A5073735090 @default.
• W2906248623 date "2018-12-21" @default.
• W2906248623 modified "2023-10-18" @default.
• W2906248623 title "Effect of memantine combined with citalopram on cognition of BPSD and moderate Alzheimer's disease: A clinical trial" @default.
• W2906248623 cites W1044629086 @default.
• W2906248623 cites W1558025250 @default.
• W2906248623 cites W1580157155 @default.
• W2906248623 cites W1639973903 @default.
• W2906248623 cites W1870479059 @default.
• W2906248623 cites W1975465128 @default.
• W2906248623 cites W1977085392 @default.
• W2906248623 cites W1978211228 @default.
• W2906248623 cites W1986367524 @default.
• W2906248623 cites W2001206572 @default.
• W2906248623 cites W2015593077 @default.
• W2906248623 cites W2015775451 @default.
• W2906248623 cites W2015993443 @default.
• W2906248623 cites W2030400690 @default.
• W2906248623 cites W2032178361 @default.
• W2906248623 cites W2041829445 @default.
• W2906248623 cites W2046244250 @default.
• W2906248623 cites W2058161128 @default.
• W2906248623 cites W2064775311 @default.
• W2906248623 cites W2073990942 @default.
• W2906248623 cites W2076233677 @default.
• W2906248623 cites W2083451860 @default.
• W2906248623 cites W2088722048 @default.
• W2906248623 cites W2090927731 @default.
• W2906248623 cites W2102426258 @default.
• W2906248623 cites W2111963393 @default.
• W2906248623 cites W2113839148 @default.
• W2906248623 cites W2118314467 @default.
• W2906248623 cites W2121403816 @default.
• W2906248623 cites W2127169081 @default.
• W2906248623 cites W2138944486 @default.
• W2906248623 cites W2143782214 @default.
• W2906248623 cites W2144098186 @default.
• W2906248623 cites W2148080316 @default.
• W2906248623 cites W2154843094 @default.
• W2906248623 cites W2167256277 @default.
• W2906248623 cites W2167862712 @default.
• W2906248623 cites W2169816003 @default.
• W2906248623 cites W2301998760 @default.
• W2906248623 cites W2511015471 @default.
• W2906248623 cites W2606873552 @default.
• W2906248623 cites W2769984699 @default.
• W2906248623 cites W2789687552 @default.
• W2906248623 cites W2790827715 @default.
• W2906248623 cites W2790963596 @default.
• W2906248623 doi "https://doi.org/10.3892/etm.2018.7124" @default.
• W2906248623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364245" @default.
• W2906248623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30783429" @default.
• W2906248623 hasPublicationYear "2018" @default.
• W2906248623 type Work @default.
• W2906248623 sameAs 2906248623 @default.
• W2906248623 citedByCount "12" @default.
• W2906248623 countsByYear W29062486232019 @default.
• W2906248623 countsByYear W29062486232020 @default.
• W2906248623 countsByYear W29062486232021 @default.
• W2906248623 countsByYear W29062486232022 @default.
• W2906248623 countsByYear W29062486232023 @default.
• W2906248623 crossrefType "journal-article" @default.
• W2906248623 hasAuthorship W2906248623A5014045791 @default.
• W2906248623 hasAuthorship W2906248623A5034911944 @default.
• W2906248623 hasAuthorship W2906248623A5039281538 @default.
• W2906248623 hasAuthorship W2906248623A5049441085 @default.
• W2906248623 hasAuthorship W2906248623A5073735090 @default.
• W2906248623 hasBestOaLocation W29062486231 @default.
• W2906248623 hasConcept C118552586 @default.
• W2906248623 hasConcept C126322002 @default.
• W2906248623 hasConcept C15744967 @default.
• W2906248623 hasConcept C197934379 @default.
• W2906248623 hasConcept C2776509080 @default.
• W2906248623 hasConcept C2777490545 @default.
• W2906248623 hasConcept C2778375690 @default.
• W2906248623 hasConcept C2779134260 @default.
• W2906248623 hasConcept C2779177272 @default.
• W2906248623 hasConcept C2779483572 @default.
• W2906248623 hasConcept C2779484449 @default.
• W2906248623 hasConcept C2780820931 @default.
• W2906248623 hasConcept C558461103 @default.
• W2906248623 hasConcept C71924100 @default.
• W2906248623 hasConceptScore W2906248623C118552586 @default.
• W2906248623 hasConceptScore W2906248623C126322002 @default.
• W2906248623 hasConceptScore W2906248623C15744967 @default.
• W2906248623 hasConceptScore W2906248623C197934379 @default.
• W2906248623 hasConceptScore W2906248623C2776509080 @default.
• W2906248623 hasConceptScore W2906248623C2777490545 @default.
• W2906248623 hasConceptScore W2906248623C2778375690 @default.
• W2906248623 hasConceptScore W2906248623C2779134260 @default.
• W2906248623 hasConceptScore W2906248623C2779177272 @default.
• W2906248623 hasConceptScore W2906248623C2779483572 @default.
• W2906248623 hasConceptScore W2906248623C2779484449 @default.
• W2906248623 hasConceptScore W2906248623C2780820931 @default.

• next