Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906258082> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2906258082 abstract "Objective: To evaluate which tests done in the neuromuscular clinic can identify respiratory impairment and describe the pattern of these abnormalities in patients with generalized myasthenia gravis (GMG) Background: Currently, respiratory tests done in the neuromuscular clinic in GMG patients are usually limited to sitting forced vital capacity (FVC), which may not be sensitive to evaluate diaphragm dysfunction. Measuring supine FVC, mean inspiratory pressure (MIP) and sniff nasal inspiratory pressure (SNIP) have been shown to grater sensitivity than upright FVC in other neuromuscular diseases but this has yet to be comprehensively studied in MG. Design/Methods: Patients with GMG attending the TGH/UHN Neuromuscular Clinic were enrolled sequentially and study procedures included MG specific neuromuscular examination, the Epworth Sleepiness Scale (ESS), University of California San Diego Shortness of Breath Questionnaire (UCSD-SOBQ) and Modified Medical Research Council Dyspnea Scale (MRC-DS). Seated and upright FVC, MIP and SNIP were tested on all patients during the clinic assessment and repeated in the pulmonary lab to confirm abnormal values. Results: 78 patients (33 males and 45 females) ages 19–82 and mean duration of disease 1 month-41 years were enrolled in the study. All patients were able to complete the study procedures in the clinic. 27% of patients were found to have abnormal upright FVC, 36% abnormal supine FVC, 21% of patients had excessive daytime sleepiness. Mean UCSD-SOBQ was 25.0 out of a possible 120 and median MRC-DS was 1 out of a possible 4. Data on MIP and SNIP is currently undergoing confirmation with the pulmonary lab. Conclusions: Patients continue to be enrolled and 120 patients are expected to be recruited by April 2016. To date, it appears that evaluating supine and upright FVC, MIP and SNIP is feasible in the neuromuscular clinic, and that abnormal FVC may be caught more frequently when performed supine compared to upright testing. Study Supported by: Muscular Dystrophy Canada Disclosure: Dr. Bril has received personal compensation for activities with CSL, Grifols, Bionevia, and UCB for consulting and research grants. Dr. Barnett Tapia has nothing to disclose." @default.
- W2906258082 created "2019-01-01" @default.
- W2906258082 creator A5043219314 @default.
- W2906258082 creator A5082026989 @default.
- W2906258082 creator A5084447270 @default.
- W2906258082 date "2017-04-18" @default.
- W2906258082 modified "2023-09-23" @default.
- W2906258082 title "Evaluation of Respiratory Testing for Patients with Myasthenia Gravis in the Neuromuscular Clinic (P3.112)" @default.
- W2906258082 hasPublicationYear "2017" @default.
- W2906258082 type Work @default.
- W2906258082 sameAs 2906258082 @default.
- W2906258082 citedByCount "0" @default.
- W2906258082 crossrefType "journal-article" @default.
- W2906258082 hasAuthorship W2906258082A5043219314 @default.
- W2906258082 hasAuthorship W2906258082A5082026989 @default.
- W2906258082 hasAuthorship W2906258082A5084447270 @default.
- W2906258082 hasConcept C125567185 @default.
- W2906258082 hasConcept C126322002 @default.
- W2906258082 hasConcept C142724271 @default.
- W2906258082 hasConcept C165637977 @default.
- W2906258082 hasConcept C1862650 @default.
- W2906258082 hasConcept C2776042228 @default.
- W2906258082 hasConcept C2776356578 @default.
- W2906258082 hasConcept C2776370487 @default.
- W2906258082 hasConcept C2776727875 @default.
- W2906258082 hasConcept C2777714996 @default.
- W2906258082 hasConcept C2778105408 @default.
- W2906258082 hasConcept C2778205975 @default.
- W2906258082 hasConcept C2778664715 @default.
- W2906258082 hasConcept C2779134260 @default.
- W2906258082 hasConcept C2779901103 @default.
- W2906258082 hasConcept C2780333948 @default.
- W2906258082 hasConcept C2781142857 @default.
- W2906258082 hasConcept C2781326671 @default.
- W2906258082 hasConcept C3018587741 @default.
- W2906258082 hasConcept C42219234 @default.
- W2906258082 hasConcept C55520419 @default.
- W2906258082 hasConcept C71924100 @default.
- W2906258082 hasConceptScore W2906258082C125567185 @default.
- W2906258082 hasConceptScore W2906258082C126322002 @default.
- W2906258082 hasConceptScore W2906258082C142724271 @default.
- W2906258082 hasConceptScore W2906258082C165637977 @default.
- W2906258082 hasConceptScore W2906258082C1862650 @default.
- W2906258082 hasConceptScore W2906258082C2776042228 @default.
- W2906258082 hasConceptScore W2906258082C2776356578 @default.
- W2906258082 hasConceptScore W2906258082C2776370487 @default.
- W2906258082 hasConceptScore W2906258082C2776727875 @default.
- W2906258082 hasConceptScore W2906258082C2777714996 @default.
- W2906258082 hasConceptScore W2906258082C2778105408 @default.
- W2906258082 hasConceptScore W2906258082C2778205975 @default.
- W2906258082 hasConceptScore W2906258082C2778664715 @default.
- W2906258082 hasConceptScore W2906258082C2779134260 @default.
- W2906258082 hasConceptScore W2906258082C2779901103 @default.
- W2906258082 hasConceptScore W2906258082C2780333948 @default.
- W2906258082 hasConceptScore W2906258082C2781142857 @default.
- W2906258082 hasConceptScore W2906258082C2781326671 @default.
- W2906258082 hasConceptScore W2906258082C3018587741 @default.
- W2906258082 hasConceptScore W2906258082C42219234 @default.
- W2906258082 hasConceptScore W2906258082C55520419 @default.
- W2906258082 hasConceptScore W2906258082C71924100 @default.
- W2906258082 hasLocation W29062580821 @default.
- W2906258082 hasOpenAccess W2906258082 @default.
- W2906258082 hasPrimaryLocation W29062580821 @default.
- W2906258082 hasRelatedWork W1994477982 @default.
- W2906258082 hasRelatedWork W2067060359 @default.
- W2906258082 hasRelatedWork W2069291546 @default.
- W2906258082 hasRelatedWork W2132927418 @default.
- W2906258082 hasRelatedWork W2179308693 @default.
- W2906258082 hasRelatedWork W2556194187 @default.
- W2906258082 hasRelatedWork W2810939929 @default.
- W2906258082 hasRelatedWork W2901798219 @default.
- W2906258082 hasRelatedWork W2906210507 @default.
- W2906258082 hasRelatedWork W2914373304 @default.
- W2906258082 hasRelatedWork W2942858067 @default.
- W2906258082 hasRelatedWork W2945041020 @default.
- W2906258082 hasRelatedWork W2971986608 @default.
- W2906258082 hasRelatedWork W2997375816 @default.
- W2906258082 hasRelatedWork W3163955979 @default.
- W2906258082 hasRelatedWork W3175091306 @default.
- W2906258082 hasRelatedWork W3176881442 @default.
- W2906258082 hasRelatedWork W3184668911 @default.
- W2906258082 hasRelatedWork W52444518 @default.
- W2906258082 hasRelatedWork W2954173358 @default.
- W2906258082 hasVolume "88" @default.
- W2906258082 isParatext "false" @default.
- W2906258082 isRetracted "false" @default.
- W2906258082 magId "2906258082" @default.
- W2906258082 workType "article" @default.