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- W2906283812 abstract "Abstract Intraneuronal accumulation of α-synuclein (αSyn) is key in the pathogenesis of Parkinson’s disease (PD). Published studies suggest that this process begins in the enteric nervous system (ENS) and propagates into the brain decades before clinical diagnosis of PD. The triggers and mechanisms underlying the accumulation of αSyn remain unknown but evidence is growing, that immune pathways and in particular colitis may play a critical role. Here we demonstrate that patients with inflammatory bowel disease (IBD) exhibit αSyn accumulation in their colon. We then confirmed in an experimental model of IBD that intestinal inflammation can trigger αSyn accumulation in the ENS of wildtype and αSyn transgenic mice. We discovered that the type and degree of inflammation modulates the extent of αSyn accumulation in the colon and that macrophage-related signaling limits this process. Remarkably, experimental colitis at three months of age exacerbated the accumulation of aggregated phospho-Serine 129 αSyn in the midbrain, including the substantia nigra, in 21-month but not 9-month-old αSyn transgenic mice. This was accompanied by loss of nigral tyrosine hydroxylase-immunoreactive neurons, another neuropathological hallmark of PD. Together, our data suggest a critical role for intestinal inflammation in the initiation and progression of PD." @default.
- W2906283812 created "2019-01-01" @default.
- W2906283812 creator A5003554880 @default.
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- W2906283812 date "2018-12-22" @default.
- W2906283812 modified "2023-09-24" @default.
- W2906283812 title "Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology" @default.
- W2906283812 cites W1515023627 @default.
- W2906283812 cites W1527671059 @default.
- W2906283812 cites W1564387586 @default.
- W2906283812 cites W1596258860 @default.
- W2906283812 cites W1618627661 @default.
- W2906283812 cites W1786270771 @default.
- W2906283812 cites W1827984733 @default.
- W2906283812 cites W1965095016 @default.
- W2906283812 cites W1966918485 @default.
- W2906283812 cites W1973113152 @default.
- W2906283812 cites W1976445933 @default.
- W2906283812 cites W1977267085 @default.
- W2906283812 cites W1979237351 @default.
- W2906283812 cites W1991604513 @default.
- W2906283812 cites W1992104307 @default.
- W2906283812 cites W1992780204 @default.
- W2906283812 cites W1995281235 @default.
- W2906283812 cites W2008859777 @default.
- W2906283812 cites W2011093795 @default.
- W2906283812 cites W2011911758 @default.
- W2906283812 cites W2024979614 @default.
- W2906283812 cites W2028807913 @default.
- W2906283812 cites W2030095917 @default.
- W2906283812 cites W2033185924 @default.
- W2906283812 cites W2046885195 @default.
- W2906283812 cites W2054107031 @default.
- W2906283812 cites W2058685901 @default.
- W2906283812 cites W2059341594 @default.
- W2906283812 cites W2066165659 @default.
- W2906283812 cites W2070142403 @default.
- W2906283812 cites W2073449985 @default.
- W2906283812 cites W2076888837 @default.
- W2906283812 cites W2084357246 @default.
- W2906283812 cites W2086787317 @default.
- W2906283812 cites W2087751760 @default.
- W2906283812 cites W2097989918 @default.
- W2906283812 cites W2099540110 @default.
- W2906283812 cites W2108108635 @default.
- W2906283812 cites W2113208645 @default.
- W2906283812 cites W2121516058 @default.
- W2906283812 cites W2131207606 @default.
- W2906283812 cites W2132310402 @default.
- W2906283812 cites W2135606077 @default.
- W2906283812 cites W2142483035 @default.
- W2906283812 cites W2143778690 @default.
- W2906283812 cites W2150656456 @default.
- W2906283812 cites W2152641033 @default.
- W2906283812 cites W2156825878 @default.
- W2906283812 cites W2161057248 @default.
- W2906283812 cites W2162999713 @default.
- W2906283812 cites W2165976376 @default.
- W2906283812 cites W2179197468 @default.
- W2906283812 cites W2326309657 @default.
- W2906283812 cites W2338538733 @default.
- W2906283812 cites W2490803709 @default.
- W2906283812 cites W2507685477 @default.
- W2906283812 cites W2528438579 @default.
- W2906283812 cites W2558041282 @default.
- W2906283812 cites W2575605891 @default.
- W2906283812 cites W2584311212 @default.
- W2906283812 cites W2586251395 @default.
- W2906283812 cites W2622719965 @default.
- W2906283812 cites W2727082859 @default.
- W2906283812 cites W2743960869 @default.
- W2906283812 cites W2745862042 @default.
- W2906283812 cites W2783610750 @default.
- W2906283812 cites W2792619350 @default.
- W2906283812 cites W2796983933 @default.
- W2906283812 cites W2802836877 @default.
- W2906283812 cites W2805466047 @default.
- W2906283812 cites W2806366257 @default.
- W2906283812 cites W2899270497 @default.
- W2906283812 cites W2902613071 @default.