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- W2906287785 abstract "Acute respiratory infections (ARI) constitutes a substantial disease burden in adults and the elderly. We aimed to identify all case-control studies investigating the potential role of respiratory viruses in the etiology of ARI in older adults aged 65 years old or more. We conducted a systematic literature review (across 7 databases) of case-control studies published from 1996 to 2017, which investigated the viral profile of older adults with and without ARI. We then computed a pooled odds ratio (OR) with 95% CI and virus–specific attributable fraction among the exposed (AFE) of 8 common viruses – respiratory syncytial virus (RSV), influenza virus (Flu), parainfluenza virus (PIV), human metapneumovirus (HMPV), adenovirus (AdV), rhinovirus (RV), bocavirus (BoV), and coronavirus (CoV). From the 16 studies included, there was strong evidence for association indicating possible causal attribution for RSV (OR 8.5 (3.9-18.5); AFE 88%), Flu (OR 8.3 (4.4-15.9); AFE 88%), PIV (OR not available (NA); AFE ~100%), HMPV (OR 9.8 (2.3-41.0); AFE 90%), AdV (OR NA; AFE ~100%), RV (OR 7.1 (3.7-13.6); AFE 86%) and CoV (OR 2.8 (2.0-4.1); AFE 65%) in older adults presenting with ARI compared to those without respiratory symptoms (asymptomatic) or healthy older adults. However, there was no significant difference in the detection of BoV in cases and controls. This review supports RSV, Flu, PIV, HMPV, AdV, RV and CoV as important causes of ARI in older adults, and provides quantitative estimates of the absolute proportion of virus–associated ARI cases to which a viral cause can be attributed." @default.
- W2906287785 created "2019-01-01" @default.
- W2906287785 creator A5012773922 @default.
- W2906287785 date "2018-09-15" @default.
- W2906287785 modified "2023-10-14" @default.
- W2906287785 title "The etiological role of common respiratory viruses in acute respiratory infections in older adults: A systematic review and meta-analysis" @default.
- W2906287785 doi "https://doi.org/10.1183/13993003.congress-2018.pa4504" @default.
- W2906287785 hasPublicationYear "2018" @default.
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