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- W2906335005 startingPage "31" @default.
- W2906335005 abstract "Over the last two decades polypharmacology has emerged as a new paradigm in drug discovery, even though developing drugs with high potency and selectivity toward a single biological target is still a major strategy. Often, targeting only a single enzyme or receptor shows lack of efficacy. High levels of inhibitor of a single target also can lead to adverse side effects. A second target may offer additive or synergistic effects to affecting the first target thereby reducing on- and off-target side effects. Therefore, drugs that inhibit multiple targets may offer a great potential for increased efficacy and reduced the adverse effects. In this review we summarize recent findings of rationally designed multitarget compounds that are aimed to improve efficacy and safety profiles compared to those that target a single enzyme or receptor. We focus on dual inhibitors/modulators that target the soluble epoxide hydrolase (sEH) as a common part of their design to take advantage of the beneficial effects of sEH inhibition." @default.
- W2906335005 created "2019-01-01" @default.
- W2906335005 creator A5002124394 @default.
- W2906335005 creator A5013074821 @default.
- W2906335005 creator A5026538320 @default.
- W2906335005 creator A5054061818 @default.
- W2906335005 creator A5066735935 @default.
- W2906335005 date "2019-02-01" @default.
- W2906335005 modified "2023-10-14" @default.
- W2906335005 title "Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity" @default.
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