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- W2906339719 abstract "Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition. Expanded SOX9+ BCs can differentiate into alveolar cells in a monolayer in vitro culture system. SOX9+ BCs can also give rise to alveolar and bronchiolar epithelium after being transplanted into injured mouse lung, with air-blood exchange system reconstructed and recipient’s lung function improved. Manipulation of lung microenvironment with Pirfenidone to suppress TGF-β signaling could further boost the transplantation efficiency. Moreover, we conducted the first autologous SOX9+ BCs transplantation clinical trial in two bronchiectasis patients. Lung tissue repair and pulmonary function enhancement was observed in patients 3~12 months after cell transplantation. Altogether our current work indicated that functional adult human lung structure can be reconstituted by orthotopic transplantation of tissue-specific stem/progenitor cells, which could be translated into a mature regenerative therapeutic strategy in near future." @default.
- W2906339719 created "2019-01-01" @default.
- W2906339719 creator A5040929986 @default.
- W2906339719 creator A5051686198 @default.
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- W2906339719 date "2018-09-15" @default.
- W2906339719 modified "2023-10-16" @default.
- W2906339719 title "Regeneration of functional lung by adult human SOX9+ airway basal cell transplantation" @default.
- W2906339719 doi "https://doi.org/10.1183/13993003.congress-2018.pa589" @default.
- W2906339719 hasPublicationYear "2018" @default.
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