FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906382259> ?p ?o ?g. }

• W2906382259 endingPage "573" @default.
• W2906382259 startingPage "567" @default.
• W2906382259 abstract "Menadione (Vitamin K3) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced hepatotoxicity in rats. Rats were randomized into five groups (A–E) of five rats each. Control rats orally received 1% dimethyl sulfoxide (DMSO) in distilled water (the vehicle for protocatechuic administration) for 7 days. In addition, control rats intraperioneally received olive oil (vehicle for menadione administration) on the 7th day. Groups B, D, and E received single dose of 100 mg/kg body weight menadione on day 7. Furthermore, groups C–E were pretreated with protocatechuic acid for 7 days. Pretreatment of rats with protocatechuic acid significantly halted menadione mediated-alterations in serum alkaline phosphatase, alanine and aspartate aminotransferases, albumin, and total bilirubin. Furthermore, menadione-mediated increase in superoxide ion and hydrogen peroxide with concomitant decrease in the activities of superoxide dismutase and catalase were significantly reversed by protocatechuic acid. Protocatechuic acid annulled menadione-mediated decrease in glutathione S-transferase and NADH: quinone oxidoreductase-1 through nuclear erythroid related factor-2 (Nrf-2). In addition, the decreased glutathione and increased glutathione disulfide, caspase-3, fragmented DNA, malondialdehyde and protein carbonyl were reversed. Results of this study show that protocatechuic acid protects against menadione-induced oxidative stress in rats by enhancing the antioxidant and phase II enzymes through Nrf-2." @default.
• W2906382259 created "2019-01-01" @default.
• W2906382259 creator A5032681517 @default.
• W2906382259 creator A5069155923 @default.
• W2906382259 date "2018-12-26" @default.
• W2906382259 modified "2023-10-18" @default.
• W2906382259 title "Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2" @default.
• W2906382259 cites W1172452390 @default.
• W2906382259 cites W1567614586 @default.
• W2906382259 cites W1581414347 @default.
• W2906382259 cites W1750690213 @default.
• W2906382259 cites W1892664396 @default.
• W2906382259 cites W1900078466 @default.
• W2906382259 cites W1905805059 @default.
• W2906382259 cites W1906197854 @default.
• W2906382259 cites W1968480618 @default.
• W2906382259 cites W1978912318 @default.
• W2906382259 cites W1991952322 @default.
• W2906382259 cites W1992900987 @default.
• W2906382259 cites W1996417742 @default.
• W2906382259 cites W1997063203 @default.
• W2906382259 cites W2006370393 @default.
• W2906382259 cites W2017119076 @default.
• W2906382259 cites W2025317059 @default.
• W2906382259 cites W2029589188 @default.
• W2906382259 cites W2057353165 @default.
• W2906382259 cites W2061635186 @default.
• W2906382259 cites W2066241876 @default.
• W2906382259 cites W2076368269 @default.
• W2906382259 cites W2080300033 @default.
• W2906382259 cites W2081261024 @default.
• W2906382259 cites W2085021556 @default.
• W2906382259 cites W2085290726 @default.
• W2906382259 cites W2094943794 @default.
• W2906382259 cites W2121653178 @default.
• W2906382259 cites W2124569198 @default.
• W2906382259 cites W2136466556 @default.
• W2906382259 cites W2169658899 @default.
• W2906382259 cites W2171549194 @default.
• W2906382259 cites W2186015928 @default.
• W2906382259 cites W2230713594 @default.
• W2906382259 cites W2339616473 @default.
• W2906382259 cites W2598407471 @default.
• W2906382259 cites W2775455229 @default.
• W2906382259 cites W2780486569 @default.
• W2906382259 cites W2790640631 @default.
• W2906382259 cites W3190406687 @default.
• W2906382259 cites W574669807 @default.
• W2906382259 doi "https://doi.org/10.1080/01480545.2018.1523187" @default.
• W2906382259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30585516" @default.
• W2906382259 hasPublicationYear "2018" @default.
• W2906382259 type Work @default.
• W2906382259 sameAs 2906382259 @default.
• W2906382259 citedByCount "12" @default.
• W2906382259 countsByYear W29063822592019 @default.
• W2906382259 countsByYear W29063822592021 @default.
• W2906382259 countsByYear W29063822592022 @default.
• W2906382259 countsByYear W29063822592023 @default.
• W2906382259 crossrefType "journal-article" @default.
• W2906382259 hasAuthorship W2906382259A5032681517 @default.
• W2906382259 hasAuthorship W2906382259A5069155923 @default.
• W2906382259 hasConcept C181199279 @default.
• W2906382259 hasConcept C185592680 @default.
• W2906382259 hasConcept C2775838275 @default.
• W2906382259 hasConcept C2776151105 @default.
• W2906382259 hasConcept C2778004101 @default.
• W2906382259 hasConcept C2778401633 @default.
• W2906382259 hasConcept C2781095387 @default.
• W2906382259 hasConcept C2781203734 @default.
• W2906382259 hasConcept C538909803 @default.
• W2906382259 hasConcept C55493867 @default.
• W2906382259 hasConcept C86803240 @default.
• W2906382259 hasConcept C98274493 @default.
• W2906382259 hasConceptScore W2906382259C181199279 @default.
• W2906382259 hasConceptScore W2906382259C185592680 @default.
• W2906382259 hasConceptScore W2906382259C2775838275 @default.
• W2906382259 hasConceptScore W2906382259C2776151105 @default.
• W2906382259 hasConceptScore W2906382259C2778004101 @default.
• W2906382259 hasConceptScore W2906382259C2778401633 @default.
• W2906382259 hasConceptScore W2906382259C2781095387 @default.
• W2906382259 hasConceptScore W2906382259C2781203734 @default.
• W2906382259 hasConceptScore W2906382259C538909803 @default.
• W2906382259 hasConceptScore W2906382259C55493867 @default.
• W2906382259 hasConceptScore W2906382259C86803240 @default.
• W2906382259 hasConceptScore W2906382259C98274493 @default.
• W2906382259 hasIssue "6" @default.
• W2906382259 hasLocation W29063822591 @default.
• W2906382259 hasOpenAccess W2906382259 @default.
• W2906382259 hasPrimaryLocation W29063822591 @default.
• W2906382259 hasRelatedWork W1990447376 @default.
• W2906382259 hasRelatedWork W2014181690 @default.
• W2906382259 hasRelatedWork W2041257525 @default.
• W2906382259 hasRelatedWork W2183540883 @default.
• W2906382259 hasRelatedWork W2509589047 @default.
• W2906382259 hasRelatedWork W3011979132 @default.
• W2906382259 hasRelatedWork W4281566553 @default.
• W2906382259 hasRelatedWork W4303437387 @default.
• W2906382259 hasRelatedWork W4315491170 @default.

• next