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- W2906403776 abstract "Pleuropulmonary blastoma (PPB) is a rare, progressive, and aggressive malignant intrathoracic tumor observed during childhood. Mutations in the DICER1 gene have been considered a major etiologic factor of PPB and cause a variety of tumor types in children and young adults. We present a 3-year-old boy with type II PPB. Multimodal treatment consisting of surgery and neoadjuvant chemotherapy was effective. DICER1 mutations were examined by Sanger sequencing, microarray comparative genomic hybridization, and microsatellite markers. The results revealed that a somatic biallelic DICER1 mutation with uniparental disomy was present in the tumor tissue." @default.
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- W2906403776 date "2020-05-01" @default.
- W2906403776 modified "2023-09-27" @default.
- W2906403776 title "Identification of Homozygous Somatic DICER1 Mutation in Pleuropulmonary Blastoma" @default.
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- W2906403776 doi "https://doi.org/10.1097/mph.0000000000001392" @default.
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