Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906447076> ?p ?o ?g. }
- W2906447076 endingPage "1668" @default.
- W2906447076 startingPage "1657" @default.
- W2906447076 abstract "Abstract Background Renal fibrosis is a key pathological feature and final common pathway leading to end-stage kidney failure in many chronic kidney diseases. Myofibroblast is the master player in renal fibrosis. However, myofibroblasts are heterogeneous. Recent studies show that bone marrow-derived macrophages transform into myofibroblasts by transforming growth factor (TGF)-β-induced macrophage–myofibroblast transition (MMT) in renal fibrosis. Methods TGF-β signaling was redirected by inhibition of β-catenin/T-cell factor (TCF) to increase β-catenin/Foxo in bone marrow-derived macrophages. A kidney fibrosis model of unilateral ureteral obstruction was performed in EGFP bone marrow chimera mouse. MMT was examined by flow cytometry analysis of GFP+F4/80+α-SMA+ cells from unilateral ureteral obstruction (UUO) kidney, and by immunofluorescent staining of bone marrow-derived macrophages in vitro. Inflammatory and anti-inflammatory cytokines were analysis by enzyme-linked immunosorbent assay. Results Inhibition of β-catenin/TCF by ICG-001 combined with TGF-β1 treatment increased β-catenin/Foxo1, reduced the MMT and inflammatory cytokine production by bone marrow-derived macrophages, and thereby, reduced kidney fibrosis in the UUO model. Conclusions Our results demonstrate that diversion of β-catenin from TCF to Foxo1-mediated transcription not only inhibits the β-catenin/TCF-mediated fibrotic effect of TGF-β, but also enhances its anti-inflammatory action, allowing therapeutic use of TGF-β to reduce both inflammation and fibrosis at least partially by changing the fate of bone marrow-derived macrophages." @default.
- W2906447076 created "2019-01-01" @default.
- W2906447076 creator A5018814816 @default.
- W2906447076 creator A5018863416 @default.
- W2906447076 creator A5026678424 @default.
- W2906447076 creator A5028972131 @default.
- W2906447076 creator A5029276236 @default.
- W2906447076 creator A5031069096 @default.
- W2906447076 creator A5034961174 @default.
- W2906447076 creator A5037993198 @default.
- W2906447076 creator A5040215906 @default.
- W2906447076 creator A5044461633 @default.
- W2906447076 creator A5045108588 @default.
- W2906447076 creator A5072372496 @default.
- W2906447076 creator A5075448214 @default.
- W2906447076 creator A5089024133 @default.
- W2906447076 date "2018-12-24" @default.
- W2906447076 modified "2023-10-16" @default.
- W2906447076 title "Fate alteration of bone marrow-derived macrophages ameliorates kidney fibrosis in murine model of unilateral ureteral obstruction" @default.
- W2906447076 cites W1985859986 @default.
- W2906447076 cites W1993600822 @default.
- W2906447076 cites W2003599465 @default.
- W2906447076 cites W2009102003 @default.
- W2906447076 cites W2011977636 @default.
- W2906447076 cites W2019268093 @default.
- W2906447076 cites W2028543411 @default.
- W2906447076 cites W2052092179 @default.
- W2906447076 cites W2138991213 @default.
- W2906447076 cites W2145497113 @default.
- W2906447076 cites W2150402351 @default.
- W2906447076 cites W2154472919 @default.
- W2906447076 cites W2158118120 @default.
- W2906447076 cites W2160109224 @default.
- W2906447076 cites W2169938366 @default.
- W2906447076 cites W2196966482 @default.
- W2906447076 cites W2255925370 @default.
- W2906447076 cites W2301044272 @default.
- W2906447076 cites W2335187016 @default.
- W2906447076 cites W2521123529 @default.
- W2906447076 cites W2589113597 @default.
- W2906447076 cites W2770476385 @default.
- W2906447076 cites W2803432473 @default.
- W2906447076 cites W4250450758 @default.
- W2906447076 doi "https://doi.org/10.1093/ndt/gfy381" @default.
- W2906447076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30590718" @default.
- W2906447076 hasPublicationYear "2018" @default.
- W2906447076 type Work @default.
- W2906447076 sameAs 2906447076 @default.
- W2906447076 citedByCount "18" @default.
- W2906447076 countsByYear W29064470762020 @default.
- W2906447076 countsByYear W29064470762021 @default.
- W2906447076 countsByYear W29064470762022 @default.
- W2906447076 countsByYear W29064470762023 @default.
- W2906447076 crossrefType "journal-article" @default.
- W2906447076 hasAuthorship W2906447076A5018814816 @default.
- W2906447076 hasAuthorship W2906447076A5018863416 @default.
- W2906447076 hasAuthorship W2906447076A5026678424 @default.
- W2906447076 hasAuthorship W2906447076A5028972131 @default.
- W2906447076 hasAuthorship W2906447076A5029276236 @default.
- W2906447076 hasAuthorship W2906447076A5031069096 @default.
- W2906447076 hasAuthorship W2906447076A5034961174 @default.
- W2906447076 hasAuthorship W2906447076A5037993198 @default.
- W2906447076 hasAuthorship W2906447076A5040215906 @default.
- W2906447076 hasAuthorship W2906447076A5044461633 @default.
- W2906447076 hasAuthorship W2906447076A5045108588 @default.
- W2906447076 hasAuthorship W2906447076A5072372496 @default.
- W2906447076 hasAuthorship W2906447076A5075448214 @default.
- W2906447076 hasAuthorship W2906447076A5089024133 @default.
- W2906447076 hasConcept C126322002 @default.
- W2906447076 hasConcept C142724271 @default.
- W2906447076 hasConcept C207865475 @default.
- W2906447076 hasConcept C2780007613 @default.
- W2906447076 hasConcept C2780091579 @default.
- W2906447076 hasConcept C2780559512 @default.
- W2906447076 hasConcept C502942594 @default.
- W2906447076 hasConcept C71924100 @default.
- W2906447076 hasConceptScore W2906447076C126322002 @default.
- W2906447076 hasConceptScore W2906447076C142724271 @default.
- W2906447076 hasConceptScore W2906447076C207865475 @default.
- W2906447076 hasConceptScore W2906447076C2780007613 @default.
- W2906447076 hasConceptScore W2906447076C2780091579 @default.
- W2906447076 hasConceptScore W2906447076C2780559512 @default.
- W2906447076 hasConceptScore W2906447076C502942594 @default.
- W2906447076 hasConceptScore W2906447076C71924100 @default.
- W2906447076 hasIssue "10" @default.
- W2906447076 hasLocation W29064470761 @default.
- W2906447076 hasLocation W29064470762 @default.
- W2906447076 hasOpenAccess W2906447076 @default.
- W2906447076 hasPrimaryLocation W29064470761 @default.
- W2906447076 hasRelatedWork W2021328706 @default.
- W2906447076 hasRelatedWork W2044930714 @default.
- W2906447076 hasRelatedWork W2174219469 @default.
- W2906447076 hasRelatedWork W2403038718 @default.
- W2906447076 hasRelatedWork W2405975318 @default.
- W2906447076 hasRelatedWork W2682978291 @default.
- W2906447076 hasRelatedWork W2965729292 @default.
- W2906447076 hasRelatedWork W2970545578 @default.
- W2906447076 hasRelatedWork W3040363790 @default.