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• W2906475671 abstract "espanolIntroduccion. El objetivo de este estudio es conocer la sensibilidad antibiotica de Pseudomonas aeruginosa productora de enfermedad invasiva en Galicia en 2013/2014, en el marco del Estudio de Vigilancia de las Resistencias Antimicrobianas. Metodos. Se analizaron 357 aislamientos de P. aeruginosa en muestras de sangre o LCR en 9 hospitales de Galicia. Las variables fueron: procedencia, datos demograficos, tipo de muestra y sensibilidad antibiotica. Se usaron puntos de corte de CLSI. Para cada antibiotico se analizaron frecuencias, casos/100.000 habitantes, concordancia de la resistencia y diferencias entre hospitales, sexo y edad. Resultados. El sexo predominante fue el masculino y la no sensibilidad superior en el grupo de 45 a 64 anos con diferencias significativas a ciprofloxacino, imipenem, tobramicina y colistina. La no sensibilidad global: piperacilina/tazobactam 18%, ciprofloxacino 28’7%, ceftazidima 17’1%, cefepime 19’7%, imipenem 23’1%, meropenem 22’1%, tobramicina 13’0%; amikacina, 7’3% y colistina 4’4%. Los casos/100.000 habitantes fueron superiores en hombres segun aumenta la edad. Sin analizar la colistina, el 57’1% de los aislamientos fueron sensibles a los otros grupos estudiados (piperacilina/tazobactam, quinolonas, ceftazidima, aminoglucosidos, carbapenems), el 19’4% fueron no sensibles a un antibiotico, 12’2% a dos, el 3’7% a tres, el 5’1% a cuatro y el 2’0% a todos los analizados. Conclusiones. De los antibioticos evaluados, los mas activos frente a P. aeruginosa fueron amikacina y colistina. Nuestros datos concuerdan con lo observado a nivel nacional, excepto para colistina. Deben evaluarse periodicamente patrones de sensibilidad de P. aeruginosa en cada zona y cada hospital para poder valorar las diferentes pautas terapeuticas. EnglishIntroduction. The aim of this study is to know the antibiotic sensitivity of the Pseudomonas aeruginosa, which produces invasive infections in Galicia in 2013/2014, in the framework of the Surveillance Study of Antimicrobial Resistance. Methods. A total of 357 isolates of P. aeruginosa were analyzed in blood or CSF samples from 9 hospitals in Galicia. The variables were: origin, demographic data, sample type and antibiotic sensitivity. CLSI breakpoints were used. For each antibiotic we analyzed frequencies, cases/100.000 inhabitants, concordance of resistance and differences between hospitals, sex and age. Results. The majority of patients were male gender and the not-sensitives were superior in the 45 to 64 age group with significant differences to ciprofloxacin, imipenem, tobramycin and colistin. The overall not-sensitivity isolates was: piperacillin/tazobactam 18%, ciprofloxacin 28.7%, ceftazidime 17.1%, cefepime 19.7%, imipenem 23.1%, meropenem 22.1%, tobramycin 13.0%, amikacin 7.3% and colistin 4.4%. The cases/100,000 inhabitants were higher in men as age increasing. Without analyzing colistin, the 57.1% of the isolates were sensitives to other antibiotics studied (piperacillin/tazobactam, quinolones, ceftazidime, aminoglycosides, carbapenems), 19.4% were not-susceptible to only one antibiotic, 12. 2% to two, 3.7% to three, 5.1% to four and 2.0% to all antibiotics tested. Conclusions. Of the antibiotics tested, the most susceptible to P. aeruginosa were amikacin and colistin. Our data are consistent with the observed ones nationwide except colistin. Sensitivity patterns of P. aeruginosa should be periodically evaluated in each area and each hospital in order to assess the different therapeutic regimens." @default.
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• W2906475671 date "2018-01-01" @default.
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• W2906475671 title "Vigilancia de la resistencia a antibióticos en enfermedad invasiva por Pseudomonas aeruginosa en Galicia: 2013-2014" @default.
• W2906475671 doi "https://doi.org/10.22546/50/1131" @default.
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