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- W2906520498 abstract "The peptide hormone relaxin mediates many biological actions including anti-fibrotic, vasodilatory, angiogenic, anti-inflammatory, anti-apoptotic, and organ protective effects across a range of tissues. At the cellular level, relaxin binds to the G protein-coupled receptor relaxin family peptide receptor 1 (RXFP1) to activate a variety of downstream signal transduction pathways. This signalling cascade is complex and also varies in diverse cellular backgrounds. Moreover, RXFP1 signalling shows crosstalk with other receptors to mediate some of its physiological functions. This review summarises known signalling pathways induced by acute versus chronic treatment with relaxin across a range of cell types, it describes RXFP1 crosstalk with other receptors, signalling pathways activated by other ligands targeting RXFP1, and it also outlines physiological relevance of RXFP1 signalling outputs. Comprehensive understanding of the mechanism of relaxin actions in fibrosis, vasodilation, as well as organ protection, will further support relaxin's clinical potential." @default.
- W2906520498 created "2019-01-01" @default.
- W2906520498 creator A5002605124 @default.
- W2906520498 creator A5003965832 @default.
- W2906520498 creator A5029379615 @default.
- W2906520498 creator A5074997845 @default.
- W2906520498 date "2019-05-01" @default.
- W2906520498 modified "2023-10-06" @default.
- W2906520498 title "Understanding relaxin signalling at the cellular level" @default.
- W2906520498 cites W1484016032 @default.
- W2906520498 cites W1487620770 @default.
- W2906520498 cites W1511208409 @default.
- W2906520498 cites W1519148279 @default.
- W2906520498 cites W1540726332 @default.
- W2906520498 cites W1607892649 @default.
- W2906520498 cites W1901488356 @default.
- W2906520498 cites W1964456035 @default.
- W2906520498 cites W1964854486 @default.
- W2906520498 cites W1964985957 @default.
- W2906520498 cites W1971724468 @default.
- W2906520498 cites W1978510787 @default.
- W2906520498 cites W1979056890 @default.
- W2906520498 cites W1979103781 @default.
- W2906520498 cites W1984990912 @default.
- W2906520498 cites W1987496015 @default.
- W2906520498 cites W1987704983 @default.
- W2906520498 cites W1992418679 @default.
- W2906520498 cites W1993178097 @default.
- W2906520498 cites W1993717649 @default.
- W2906520498 cites W1995158939 @default.
- W2906520498 cites W1996038926 @default.
- W2906520498 cites W1997023449 @default.
- W2906520498 cites W1997835558 @default.
- W2906520498 cites W2000750638 @default.
- W2906520498 cites W2001391676 @default.
- W2906520498 cites W2003390414 @default.
- W2906520498 cites W2018492901 @default.
- W2906520498 cites W2019488408 @default.
- W2906520498 cites W2020765596 @default.
- W2906520498 cites W2020780987 @default.
- W2906520498 cites W2021717908 @default.
- W2906520498 cites W2026038641 @default.
- W2906520498 cites W2029159827 @default.
- W2906520498 cites W2031830485 @default.
- W2906520498 cites W2033190068 @default.
- W2906520498 cites W2033204507 @default.
- W2906520498 cites W2036381031 @default.
- W2906520498 cites W2041479810 @default.
- W2906520498 cites W2043480400 @default.
- W2906520498 cites W2043829191 @default.
- W2906520498 cites W2045045118 @default.
- W2906520498 cites W2049682064 @default.
- W2906520498 cites W2051498264 @default.
- W2906520498 cites W2057839958 @default.
- W2906520498 cites W2058160393 @default.
- W2906520498 cites W2062094048 @default.
- W2906520498 cites W2066113694 @default.
- W2906520498 cites W2067231265 @default.
- W2906520498 cites W2069500561 @default.
- W2906520498 cites W2076345295 @default.
- W2906520498 cites W2077833316 @default.
- W2906520498 cites W2082370121 @default.
- W2906520498 cites W2084696027 @default.
- W2906520498 cites W2094370101 @default.
- W2906520498 cites W2094755760 @default.
- W2906520498 cites W2097511872 @default.
- W2906520498 cites W2098083586 @default.
- W2906520498 cites W2099258199 @default.
- W2906520498 cites W2100769996 @default.
- W2906520498 cites W2105172891 @default.
- W2906520498 cites W2107356121 @default.
- W2906520498 cites W2109822459 @default.
- W2906520498 cites W2111459296 @default.
- W2906520498 cites W2113179714 @default.
- W2906520498 cites W2114351224 @default.
- W2906520498 cites W2116293808 @default.
- W2906520498 cites W2117759638 @default.
- W2906520498 cites W2118552848 @default.
- W2906520498 cites W2118797909 @default.
- W2906520498 cites W2120200350 @default.
- W2906520498 cites W2125200790 @default.
- W2906520498 cites W2129416181 @default.
- W2906520498 cites W2130632774 @default.
- W2906520498 cites W2130933593 @default.
- W2906520498 cites W2136428504 @default.
- W2906520498 cites W2137814699 @default.
- W2906520498 cites W2138742410 @default.
- W2906520498 cites W2138819935 @default.
- W2906520498 cites W2139138080 @default.
- W2906520498 cites W2144157272 @default.
- W2906520498 cites W2144468109 @default.
- W2906520498 cites W2145387518 @default.
- W2906520498 cites W2145733556 @default.
- W2906520498 cites W2147819241 @default.
- W2906520498 cites W2150784397 @default.
- W2906520498 cites W2151825176 @default.
- W2906520498 cites W2151909906 @default.
- W2906520498 cites W2152736965 @default.