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- W2906543169 abstract "Although converging evidence point to alpha-synuclein (a-syn) aggregation and Lewy body (LB) formation as central events in Parkinson's disease (PD), the molecular mechanisms that regulate these processes and their role in disease pathogenesis remain poorly understood. Herein, we applied an integrative biochemical, structural and imaging approach to elucidate the sequence, molecular and cellular mechanisms that regulate LB formation in primary neurons. Our results establish that post-fibrillization C-terminal truncation mediated by calpains 1 and 2 and potentially other enzymes, plays critical roles in regulating a-syn seeding, fibrillization and orchestrates many of the events associated with LB formation and maturation. These findings combined with the abundance of a-syn truncated species in LBs and pathological a-syn aggregates have significant implications for ongoing efforts to develop therapeutic strategies based on targeting the C-terminus of a-syn or proteolytic processing of this region." @default.
- W2906543169 created "2019-01-01" @default.
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- W2906543169 date "2018-12-19" @default.
- W2906543169 modified "2023-10-01" @default.
- W2906543169 title "The making of a Lewy body: the role of alpha-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions." @default.
- W2906543169 cites W152096304 @default.
- W2906543169 cites W1572679174 @default.
- W2906543169 cites W1590614500 @default.
- W2906543169 cites W1601052838 @default.
- W2906543169 cites W1807475000 @default.
- W2906543169 cites W1943532636 @default.
- W2906543169 cites W1956133826 @default.
- W2906543169 cites W1965095016 @default.
- W2906543169 cites W1973608140 @default.
- W2906543169 cites W1977267085 @default.
- W2906543169 cites W1983210835 @default.
- W2906543169 cites W1989913002 @default.
- W2906543169 cites W1998388651 @default.
- W2906543169 cites W2000299127 @default.
- W2906543169 cites W2001407922 @default.
- W2906543169 cites W2003181166 @default.
- W2906543169 cites W2007671889 @default.
- W2906543169 cites W2011332000 @default.
- W2906543169 cites W2019933368 @default.
- W2906543169 cites W2021267750 @default.
- W2906543169 cites W2024045695 @default.
- W2906543169 cites W2025575563 @default.
- W2906543169 cites W2027868656 @default.
- W2906543169 cites W2029479609 @default.
- W2906543169 cites W2032392617 @default.
- W2906543169 cites W2041134571 @default.
- W2906543169 cites W2042553854 @default.
- W2906543169 cites W2049104084 @default.
- W2906543169 cites W206097472 @default.
- W2906543169 cites W2062763778 @default.
- W2906543169 cites W2072427499 @default.
- W2906543169 cites W2075793841 @default.
- W2906543169 cites W2080765656 @default.
- W2906543169 cites W2081100775 @default.
- W2906543169 cites W2082283179 @default.
- W2906543169 cites W2085784901 @default.
- W2906543169 cites W2093171209 @default.
- W2906543169 cites W2107451956 @default.
- W2906543169 cites W2108865709 @default.
- W2906543169 cites W2123591482 @default.
- W2906543169 cites W2130128490 @default.
- W2906543169 cites W2138070282 @default.
- W2906543169 cites W2143547926 @default.
- W2906543169 cites W2144139389 @default.
- W2906543169 cites W2144433399 @default.
- W2906543169 cites W2151796024 @default.
- W2906543169 cites W2152543350 @default.
- W2906543169 cites W2158745133 @default.
- W2906543169 cites W2168126805 @default.
- W2906543169 cites W2264082276 @default.
- W2906543169 cites W2411540334 @default.
- W2906543169 cites W2503377259 @default.
- W2906543169 cites W2506142970 @default.
- W2906543169 cites W2512282616 @default.
- W2906543169 cites W2521336258 @default.
- W2906543169 cites W2579105907 @default.
- W2906543169 cites W2591620984 @default.
- W2906543169 cites W2603410215 @default.
- W2906543169 cites W2615508363 @default.
- W2906543169 cites W2616311495 @default.
- W2906543169 cites W2626116524 @default.
- W2906543169 cites W2730417813 @default.
- W2906543169 cites W2746087605 @default.
- W2906543169 cites W2768313503 @default.
- W2906543169 cites W2768638419 @default.
- W2906543169 cites W2791533445 @default.
- W2906543169 cites W2804964390 @default.
- W2906543169 cites W2823173529 @default.
- W2906543169 cites W2895256968 @default.
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- W2906543169 doi "https://doi.org/10.1101/500058" @default.
- W2906543169 hasPublicationYear "2018" @default.
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