Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906548750> ?p ?o ?g. }
- W2906548750 endingPage "184" @default.
- W2906548750 startingPage "165" @default.
- W2906548750 abstract "Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and oxidative stress have been greatly implicated in the progression of aging, along with the pathogenesis of age-related neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Although antioxidant therapy has been proposed for the prevention and treatment of age-related NDs, unraveling the molecular mechanisms of mitochondrial dysfunction can lead to significant progress in the development of effective treatments against such diseases. Aging is associated with the generation and accumulation of reactive oxygen species (ROS) that are the major contributors to oxidative stress. Oxidative stress is caused because of the imbalance between the production of ROS and their oxidation, which can affect the mitochondrial respiratory chain function, thereby altering the membrane permeability and calcium homeostasis, along with increasing the heteroplasmic mtDNA and weakening the mitochondrial defense systems. Mitochondrial dysfunction mainly affects mitochondrial biogenesis and dynamics that are prominent in several age-related NDs. Mitochondrial dysfunction has a crucial role in the pathophysiology of age-related NDs. Several mitochondria targeted strategies, such as enhancing the antioxidant bioavailability via novel delivery systems, identifying unique mitochondrial proteins as specific drug targets, investigating the signaling pathways of mitochondrial biogenesis and dynamics, and identifying effective natural products are potentially effective to counteract mitochondrial dysfunction-related NDs." @default.
- W2906548750 created "2019-01-01" @default.
- W2906548750 creator A5074632953 @default.
- W2906548750 creator A5076929473 @default.
- W2906548750 date "2019-02-01" @default.
- W2906548750 modified "2023-10-14" @default.
- W2906548750 title "Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies" @default.
- W2906548750 cites W1479935944 @default.
- W2906548750 cites W1486617476 @default.
- W2906548750 cites W1512824421 @default.
- W2906548750 cites W1524417563 @default.
- W2906548750 cites W1524718556 @default.
- W2906548750 cites W1539334271 @default.
- W2906548750 cites W1559791712 @default.
- W2906548750 cites W1566211063 @default.
- W2906548750 cites W1578882407 @default.
- W2906548750 cites W1600928275 @default.
- W2906548750 cites W1722845210 @default.
- W2906548750 cites W1903564790 @default.
- W2906548750 cites W1934800228 @default.
- W2906548750 cites W1950475967 @default.
- W2906548750 cites W1964876127 @default.
- W2906548750 cites W1967445833 @default.
- W2906548750 cites W1968362444 @default.
- W2906548750 cites W1968448866 @default.
- W2906548750 cites W1969156376 @default.
- W2906548750 cites W1969800514 @default.
- W2906548750 cites W1971082641 @default.
- W2906548750 cites W1972991508 @default.
- W2906548750 cites W1973083723 @default.
- W2906548750 cites W1976180551 @default.
- W2906548750 cites W1977539185 @default.
- W2906548750 cites W1978238824 @default.
- W2906548750 cites W1978631832 @default.
- W2906548750 cites W1979524690 @default.
- W2906548750 cites W1980379444 @default.
- W2906548750 cites W1982441008 @default.
- W2906548750 cites W1983430070 @default.
- W2906548750 cites W1985591678 @default.
- W2906548750 cites W1990171977 @default.
- W2906548750 cites W1991505929 @default.
- W2906548750 cites W1993250284 @default.
- W2906548750 cites W1993963228 @default.
- W2906548750 cites W1995706959 @default.
- W2906548750 cites W1999046788 @default.
- W2906548750 cites W2000719268 @default.
- W2906548750 cites W2002088854 @default.
- W2906548750 cites W2004129180 @default.
- W2906548750 cites W2004205778 @default.
- W2906548750 cites W2005381354 @default.
- W2906548750 cites W2007047564 @default.
- W2906548750 cites W2007454584 @default.
- W2906548750 cites W2008241759 @default.
- W2906548750 cites W2008649582 @default.
- W2906548750 cites W2009145663 @default.
- W2906548750 cites W2009804847 @default.
- W2906548750 cites W2011166795 @default.
- W2906548750 cites W2012062523 @default.
- W2906548750 cites W2014140012 @default.
- W2906548750 cites W2016139827 @default.
- W2906548750 cites W2017115444 @default.
- W2906548750 cites W2018951168 @default.
- W2906548750 cites W2020220420 @default.
- W2906548750 cites W2021439462 @default.
- W2906548750 cites W2022267544 @default.
- W2906548750 cites W2024384082 @default.
- W2906548750 cites W2024595059 @default.
- W2906548750 cites W2025674512 @default.
- W2906548750 cites W2029553530 @default.
- W2906548750 cites W2031535129 @default.
- W2906548750 cites W2032040905 @default.
- W2906548750 cites W2033234733 @default.
- W2906548750 cites W2034430821 @default.
- W2906548750 cites W2036863248 @default.
- W2906548750 cites W2037064466 @default.
- W2906548750 cites W2040076400 @default.
- W2906548750 cites W2041255615 @default.
- W2906548750 cites W2042431503 @default.
- W2906548750 cites W2042628846 @default.
- W2906548750 cites W2044897807 @default.
- W2906548750 cites W2047129735 @default.
- W2906548750 cites W2048553024 @default.
- W2906548750 cites W2048875992 @default.
- W2906548750 cites W2049045958 @default.
- W2906548750 cites W2049970571 @default.
- W2906548750 cites W2050303681 @default.
- W2906548750 cites W2053062221 @default.
- W2906548750 cites W2053671179 @default.
- W2906548750 cites W2059009119 @default.
- W2906548750 cites W2060814375 @default.
- W2906548750 cites W2064636913 @default.
- W2906548750 cites W2066265394 @default.
- W2906548750 cites W2067958598 @default.
- W2906548750 cites W2068337326 @default.
- W2906548750 cites W2068700852 @default.
- W2906548750 cites W2071012903 @default.
- W2906548750 cites W2071645144 @default.
- W2906548750 cites W2072117025 @default.