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• W2906553203 abstract "Plasmodium falciparum, the causative agent of severe malaria, is itself not considered a carcinogenic organism. However, the occurrence of endemic Burkitt lymphoma (eBL; first described in 1958 by Dennis Burkitt in Uganda) in tropical Africa is apparently associated with intense and repeated exposure to P. falciparum infections. Concurrent infection with P. falciparum malaria and Epstein-Barr virus (EBV) is regarded the main risk factor for the development of eBL. The precise mechanisms of how interactions of these two pathogens induce eBL pathogenesis have, however, been an unsolved mystery for decades. In an article in the present issue of EBioMedicine, Derkach and colleagues have assessed antibody reactivity to 13 P. falciparum erythrocyte membrane protein 1 (PfEMP1) and 3 non-PfEMP1 antigens, (potential targets of acquired immune responses, in two sex-age matched study cohorts from Ghana (150 eBL cases and 150 controls) and Uganda (194 eBL cases and 600 controls) (Derkach et al. [[1]Derkach A. Otim I. Ruth M. Pfeiffer R.M. et al.Associations between IgG Reactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Antigens and Burkitt Lymphoma in Ghana and Uganda Case-Control Studies.EBioMedicine. 2019; (This Paper yet to be published in this issue)https://www.ebiomedicine.com/article/S2352-3964(18)30597-8/fulltextSummary Full Text Full Text PDF PubMed Scopus (12) Google Scholar]). Lower IgG reactivity to PfEMP1 antigens in eBL cases compared to controls was observed. In addition, the study calls attention to the salient role of the cysteine-rich interdomain region α1 (CIDRα1) in the pathophysiology of malaria and the predisposition to attenuated humoral immunity, contributing to the frequent occurrence of eBL in tropical Africa where P. falciparum malaria is holoendemic. The study showed that IgG reactivity to the CIDRα1 domains, which are associated with severe malaria, was stronger than to other CIDR domains in cases and controls, and that eBL cases reacted to fewer antigens than controls, both in Ghana and Uganda (Derkach et al. [[1]Derkach A. Otim I. Ruth M. Pfeiffer R.M. et al.Associations between IgG Reactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Antigens and Burkitt Lymphoma in Ghana and Uganda Case-Control Studies.EBioMedicine. 2019; (This Paper yet to be published in this issue)https://www.ebiomedicine.com/article/S2352-3964(18)30597-8/fulltextSummary Full Text Full Text PDF PubMed Scopus (12) Google Scholar]). IgG reactivity to eleven of the PfEMP1-derived antigens was lower in eBL cases compared to controls in Ghana. A corresponding trend was observed also in the Ugandan study group with low IgG reactivity to three PfEMP1-derived antigens. Inverse associations of eBL and IgG reactivity to all CIDR domains were observed, indicating that reduced IgG reactivity in eBL is not associated with the function of PfEMP1. In young children, when maternal antibodies decrease in circulation, EBV infection occurs and is mostly asymptomatic. The increased risk of eBL is not due to EBV infection alone, but also to recurrent and intense exposure to malaria parasites. The immune system is under relentless stress in children less than 5 years through repeated malarial infections with high parasite burdens. The cumulative exposure over years provides some degree of immunity, but the interaction of P. falciparum and B cells is apparently key in the eBL oncogenesis. Proposed mechanisms include extensive expansion of a monoclonal EBV-infected B cell population, suppression of EBV-specific T-cell immunity, reactivation and massive propagation of EBV, and AID-dependent genomic translocation [[2]van T.H. Brindley P.J. Meyer C.G. Velavan T.P. Parasite infection, carcinogenesis and human malignancy.EBioMedicine. 2017 February; 15: 12-23Summary Full Text Full Text PDF PubMed Scopus (84) Google Scholar]. During the course of malaria, expansion of EBV-infected B cells occurs. The PfEMP1 expressing erythrocytes bind to host endothelial receptors and evade destruction in the spleen, thus expanding PfEMP1 encoding var. genes and, subsequently, various PfEMP1 adhesion phenotypes. P. falciparum-infected erythrocytes directly adhere to and activate B cells through PfEMP1 domains [[3]Simone O. Bejarano M.T. Pierce S.K. Antonaci S. Wahlgren M. Troye-Blomberg M. et al.TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1alpha-driven human polyclonal B-cell activation.Acta Trop. 2011 August; 119: 144-150Crossref PubMed Scopus (38) Google Scholar]. This interaction increases expression of Toll like receptors, in particular TLR7 and TLR 10, subjecting B cells to TLR 9 signalling and persistently activating B cells [[3]Simone O. Bejarano M.T. Pierce S.K. Antonaci S. Wahlgren M. Troye-Blomberg M. et al.TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1alpha-driven human polyclonal B-cell activation.Acta Trop. 2011 August; 119: 144-150Crossref PubMed Scopus (38) Google Scholar]. P. falciparum infection was previously found associated with increased proliferation and transformation of EBV-infected cells both in children with clinical and with asymptomatic malaria [[4]Moormann A.M. Chelimo K. Sumba O.P. Lutzke M.L. Ploutz-Snyder R. Newton D. et al.Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children.J Infect Dis. 2005 April 15; 191: 1233-1238Crossref PubMed Scopus (156) Google Scholar]. Derkach and colleagues show strong reactivity against PfEMP1 antigens in the control individuals (Derkach et al. [[1]Derkach A. Otim I. Ruth M. Pfeiffer R.M. et al.Associations between IgG Reactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Antigens and Burkitt Lymphoma in Ghana and Uganda Case-Control Studies.EBioMedicine. 2019; (This Paper yet to be published in this issue)https://www.ebiomedicine.com/article/S2352-3964(18)30597-8/fulltextSummary Full Text Full Text PDF PubMed Scopus (12) Google Scholar]). This suggests that children were obviously exposed to malaria and the absence of clinical symptoms is a result of naturally acquired immunity, the ability to restrain the parasite burden. A yet other mechanism is suppression of EBV-specific T-cell immunity. In malaria, EBV-specific T cells fail to control EBV-infected cells, causing abnormal proliferation of EBV infected B cells as observed in eBL [[5]Whittle H.C. Brown J. Marsh K. Greenwood B.M. Seidelin P. Tighe H. et al.T-cell control of Epstein-Barr virus-infected B cells is lost during P. falciparum malaria.Nature. 1984 November 29; 312: 449-450Crossref PubMed Scopus (195) Google Scholar]. EBV viral loads are also associated with the development of eBL [[6]Asito A.S. Piriou E. Odada P.S. Fiore N. Middeldorp J.M. Long C. et al.Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study.Infect Agent Cancer. 2010 July 28; 5: 13Crossref PubMed Scopus (35) Google Scholar]. Reactivation of EBV may also be induced by P. falciparum. It was shown that EBV-DNA levels in plasma of children and pregnant women with malaria were higher than among those without malaria, indicating that viral replication is increased during malarial episodes [[7]Ogolla S. Daud I.I. Asito A.S. Sumba O.P. Ouma C. Vulule J. et al.Reduced transplacental transfer of a subset of Epstein-Barr virus-specific antibodies to neonates of mothers infected with plasmodium falciparum malaria during pregnancy.Clin Vaccine Immunol. 2015 November; 22: 1197-1205Crossref PubMed Scopus (17) Google Scholar]. Binding of latently EBV-infected B cells to PfEMP1 directly switches the virus into a lytic replication cycle and CIDRα1 stimulates EBV production [[8]Chene A. Donati D. Guerreiro-Cacais A.O. Levitsky V. Chen Q. Falk K.I. et al.A molecular link between malaria and Epstein-Barr virus reactivation.PLoS Pathog. 2007 June; 3e80Crossref PubMed Scopus (135) Google Scholar]. P. falciparum malaria may also promote genomic instability and activation-induced cytidine deaminase (AID)-dependent B cell lymphoma [[9]Robbiani D.F. Deroubaix S. Feldhahn N. Oliveira T.Y. Callen E. Wang Q. et al.Plasmodium infection promotes genomic instability and AID-dependent B cell lymphoma.Cell. 2015 August 13; 162: 727-737Summary Full Text Full Text PDF PubMed Scopus (103) Google Scholar]. The intensity of malaria transmission is associated with AID expression levels in the presence of EBV. Therefore, AID is a key player that induces Plasmodium-induced lymphomagenesis [[10]Wilmore J.R. Asito A.S. Wei C. Piriou E. Sumba P.O. Sanz I. et al.AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus.Int J Cancer. 2015 March 15; 136: 1371-1380Crossref PubMed Scopus (20) Google Scholar]. Taken together, malaria is not a direct trigger of eBL, but infection rather modifies the lymphoma phenotype and the onset of eBL. Understanding such multifactorial mechanisms involved in the development of eBL has important repercussions in piecing together eBL carcinogenesis. The author declared no conflicts of interest. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studieseBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk. Full-Text PDF Open Access" @default.
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• W2906553203 title "Epstein-Barr virus, malaria and endemic Burkitt lymphoma" @default.
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