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- W2906564970 abstract "<b>Background:</b> Lung fibrosis is a lethal interstitial disease characterized by a massive proliferation of fibroblast leading to chronic respiratory failure. Current treatments are ineffective and have significant adverse effects. Therapeutic trials with plant extracts rich in bioactive molecules can be a good alternative. <b>Aims and objectives:</b> We aimed to investigate whether Date Palm Sap (DPS) rich in bioactive vitamins and phenolic compounds. compounds, can play a protective effect on Bleomycin (BLM)-induced lung fibrosis in rats. <b>Methods:</b> Animals were randomly divided into 4 groups of 8 rats each. G1: Control group, G2: BLM group, G3: DPS group, G4: BLM + DPS group. BLM was administered by a single intra tracheal injection (4 mg/Kg) to G2 and G4. DPS was administered intraperitoneally at a dose of (45 mg / kg/day) for 3 weeks to G3 and G4. The later received DPS 3 days after BLM injection. At the end of the protocol, all rats were sacrificed and lungs were extracted. Fibrosis was assessed conforming fibrosis Ashcroft score. Antioxidant effects of DPS and hydroxyproline content in lung tissues were studied using standard spectrophotometric methods. <b>Results:</b> Histological assessments revealed a significant reduction in fibrosis score in G4 compared to G2. BLM increased Hydroxyproline, Malondialdehyde and Superoxide Dismutase content and decreased Catalase activity in G2 compared to G1. Treatment by DPS (G4) normalized significantly the activities of antioxidant enzymes and decreased Malondialdehyde and hydroxyproline levels compared to G2. <b>Conclusion:</b> This study demonstrated that DPS can attenuate BLM induced lung fibrosis by its anti-oxidative and anti-fibrotic effects" @default.
- W2906564970 created "2019-01-01" @default.
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- W2906564970 date "2018-09-15" @default.
- W2906564970 modified "2023-09-26" @default.
- W2906564970 title "The efficacy of Phoenix dactylifera L. sap for the treatment of lung injury in a murine model of pulmonary fibrosis" @default.
- W2906564970 doi "https://doi.org/10.1183/13993003.congress-2018.pa3718" @default.
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