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- W2906565140 abstract "Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of other UCP paralogs remain less clear. Here, we critically discuss the existence of brain UCPs and their potential roles. Applying phylogenetic classification of novel UCPs, we summarize the evidence for brain UCP1 among vertebrates, the role of UCP2 in specific brain areas, and the existence of brain-specific UCPs. The phylogenetic analyses and discussion on functional data should alert the scientific community that the molecular function of so-called UCP1 homologues is by far not clarified and possibly relates to neither thermogenesis nor mitochondrial uncoupling." @default.
- W2906565140 created "2019-01-01" @default.
- W2906565140 creator A5052766513 @default.
- W2906565140 creator A5088670288 @default.
- W2906565140 date "2019-03-01" @default.
- W2906565140 modified "2023-10-17" @default.
- W2906565140 title "Molecular evolution of uncoupling proteins and implications for brain function" @default.
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- W2906565140 doi "https://doi.org/10.1016/j.neulet.2018.12.027" @default.
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