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- W2906566279 abstract "Challenges in obtaining tissue specimens from patients with brain tumours limit the diagnosis and molecular characterisation and impair the development of better therapeutic approaches. The analysis of cell-free tumour DNA in plasma (considered a liquid biopsy) has facilitated the characterisation of extra-cranial tumours. However, cell-free tumour DNA in plasma is limited in quantity and may not reliably capture the landscape of genomic alterations of brain tumours. Here, we review recent work assessing the relevance of cell-free tumour DNA from cerebrospinal fluid in the characterisation of brain cancer. We focus on the advances in the use of the cerebrospinal fluid as a source of cell-free tumour DNA to facilitate diagnosis, reveal actionable genomic alterations, monitor responses to therapy, and capture tumour heterogeneity in patients with primary brain tumours and brain and leptomeningeal metastases. Profiling cerebrospinal fluid cell-free tumour DNA provides the opportunity to precisely acquire and monitor genomic information in real time and guide precision therapies." @default.
- W2906566279 created "2019-01-01" @default.
- W2906566279 creator A5017177249 @default.
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- W2906566279 creator A5077744058 @default.
- W2906566279 creator A5086060519 @default.
- W2906566279 date "2019-02-01" @default.
- W2906566279 modified "2023-10-16" @default.
- W2906566279 title "Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases" @default.
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- W2906566279 doi "https://doi.org/10.1093/annonc/mdy544" @default.
- W2906566279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30576421" @default.
- W2906566279 hasPublicationYear "2019" @default.
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