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- W2906573225 abstract "Background:Hepatocellularcarcinoma(HCC)isthefifthmostcommonmalignancyinthe world.InEgypt,HCCwasreportedtoaccountforabout4.7%ofchronicliverdisease(CLD) patients.Squamouscellcarcinomaantigen(SCCA)hasbeenreportedtobestronglyexpressed inHCCtissuehamperingitsextensiveuseinclinicalpractice. Aim:Studythevalueofserumsquamouscellcarcinomaantigen(SCCA)forscreeningof HCC. MaterialsM groupBsuclassifiedintothreecategoriesaccordingtoCHILD-PUGHscoreincluded30 patients,matchedforsexandage.Allgroupsweresubjectedtothoroughhistorytaking,full clinicalexamination,andlaboratoryinvestigationsincludingliverfunctions,viralmarkers,and AFPandSCCAestimationusingELISAtechnique. Results:ThisstudyrevealedahighlysignificantdifferencebetweenpatientswithHCCand CLDregardingserumSCCAlevelsbeinghigheringroupA(10.35±20.677)thangroup B(1.64±2.462)(p=0.02).SCCAlevelwaselevatedinpatientswithHCCwithnormalAFPlevels representingitsusefulroleinearlydetectionandfollow-upofpatientstreatedforHCC.The cut-offvaluewasestablishedat2ng/mlwithsensitivityof80%andspecificityof70%). Conclusion:SCCAcouldrepresentausefultoolasamarkerfordetectionofHCC." @default.
- W2906573225 created "2019-01-01" @default.
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- W2906573225 date "2018-04-01" @default.
- W2906573225 modified "2023-09-23" @default.
- W2906573225 title "Clinical value of screening serum squamous cell carcinoma antigen (SCCA) for HCC" @default.
- W2906573225 cites W1986414102 @default.
- W2906573225 cites W2143502485 @default.
- W2906573225 doi "https://doi.org/10.12816/ejhm.2018.16964" @default.
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