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- W2906574430 abstract "Background: Calprotectin is found extensively in the cytoplasm of neutrophils and it is released predominately in inflammatory processes. Calprotectin is released locally which suggests that it is a sensitive indicator of inflammation. Bronchiolitis Obliterans (BO) describes a pathologic alteration of small airways which begins with an initial injury and is followed by a distinctive inflammatory response. Aims: The aim of this study is to investigate for the first time to what extent calprotectin is increased in sputum of BO patients and whether it can be used as inflammatory marker. Methods: 28 patients with BO median age 14.2 years (6.2-27.3) and 18 healthy controls median age 16.2 years (7.6-25.0) were investigated by bodyplethysmography, lung clearance index (LCI) and induced sputum. Cell counts, cytokines IL-1β, IL-6 and IL-8 were measured by cytometric bead array and sputum calprotectin by commercial ELISA. Results: Patients with BO revealed compromised lung function: FVC, FEV1, MEF25 were decreased while RV/TLC and LCI were significantly increased (12.1 BO vs. 7.1 controls). Sputum of BO patients showed significantly increased neutrophils, IL-8 and calprotectin (Calprotectin:median 6428.5; 30.6-84000ng/ml vs. controls:median 949.6; 135.0-2886.4ng/ml). There was a significant correlation between calprotectin and IL-8 (rho=0,871; p Conclusion: Calprotectin is significantly increased in BO which emphasizes the ongoing neutrophilic inflammatory process. Further investigations are required to show whether calprotectin is a sensible surrogate marker to support the diagnosis of BO and monitoring of anti-inflammatory therapy" @default.
- W2906574430 created "2019-01-01" @default.
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- W2906574430 date "2018-09-15" @default.
- W2906574430 modified "2023-09-27" @default.
- W2906574430 title "Calprotectin as new sensitive marker of neutrophilic inflammation in patients with bronchiolitis obliterans" @default.
- W2906574430 doi "https://doi.org/10.1183/13993003.congress-2018.pa4649" @default.
- W2906574430 hasPublicationYear "2018" @default.
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