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• W2906618529 abstract "Local translation in neurites is considered as an important mechanism to modulate synaptic plasticity of neurons. However, it is hard to specifically express a protein-coding gene in neurites. Recently, the 5'-UTR of Tick-borne encephalitis virus (TBEV) is reported to be able to drive its RNA to the dendrites of infected neurons, as a cis-acting RNA element. To construct a neurite specific gene expression system, present study tested the ability of 5'-UTR of TBEV to bring a mRNA (mCherry CDS) to the neurites for targeted expression. We showed that both the 5'-UTR of TBEV and the 3'-UTR of Actb gene could bring the protein coding mRNA to neurites, and the TBEV 5'-UTR bearing mRNA was more robust targeted into neurites. About the safety of the TBEV 5'-UTR, there was no obvious cytotoxicity to the neurons when adding either cis-acting RNA element to the protein-expressing plasmid vectors. Given the short length and high efficiency of the TBEV 5'-UTR, the 5'-UTR of TBEV were assemble into an AAV plasmid to produce virus particles for expressing protein-coding gene in vivo. After two weeks infection, the TBEV 5'-UTR infected neurons expressed more mCherry protein in their neurites. In conclusion, as a short while high efficient cis-acting RNA element, TBEV 5'-UTR could be useful in neural system research and locally express synaptic proteins more precisely." @default.
• W2906618529 created "2019-01-01" @default.
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• W2906618529 date "2019-02-01" @default.
• W2906618529 modified "2023-10-15" @default.
• W2906618529 title "Dendritic targeted mRNA expression via a cis-acting RNA UTR element" @default.
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• W2906618529 doi "https://doi.org/10.1016/j.bbrc.2018.12.137" @default.
• W2906618529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30594399" @default.
• W2906618529 hasPublicationYear "2019" @default.
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