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- W2906678776 abstract "The relevance of co-crystals for pharmaceutical development is demonstrated by the constant growth of the number of papers and patents published in the two last decades. Co-crystallization appears to be an efficient means to modulate the solid state properties of a pharmaceutical active ingredient (API) within the crystalline state. It is also a crystal engineering approach enabling to prepare original materials, including co-drugs. Co-crystallization is therefore a route to innovation and opens perspectives to patent protection. Alternatively, co-crystal formation may represent an undesired or unexpected outcome of molecular complexation, for example in the drug product. This observation underlines the importance of a detailed study on the solid state chemistry not only of the pure API, but also of its combinations with the individual components in the formulation." @default.
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- W2906678776 date "2018-12-10" @default.
- W2906678776 modified "2023-10-17" @default.
- W2906678776 title "Alternative Solid Forms: Co‐crystals" @default.
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- W2906678776 doi "https://doi.org/10.1002/9783527697847.ch3" @default.
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