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• W2906768191 endingPage "e1007886" @default.
• W2906768191 startingPage "e1007886" @default.
• W2906768191 abstract "Meiotic recombination, which is necessary to ensure that homologous chromosomes segregate properly, begins with the induction of meiotic DNA double-strand breaks (DSBs) and ends with the repair of a subset of those breaks into crossovers. Here we investigate the roles of two paralogous genes, CG12200 and CG31053, which we have named Narya and Nenya, respectively, due to their relationship with a structurally similar protein named Vilya. We find that narya recently evolved from nenya by a gene duplication event, and we show that these two RING finger domain-containing proteins are functionally redundant with respect to a critical role in DSB formation. Narya colocalizes with Vilya foci, which are known to define recombination nodules, or sites of crossover formation. A separation-of-function allele of narya retains the capacity for DSB formation but cannot mature those DSBs into crossovers. We further provide data on the physical interaction of Narya, Nenya and Vilya, as assayed by the yeast two-hybrid system. Together these data support the view that all three RING finger domain-containing proteins function in the formation of meiotic DNA DSBs and in the process of crossing over." @default.
• W2906768191 created "2019-01-11" @default.
• W2906768191 creator A5012962068 @default.
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• W2906768191 date "2019-01-07" @default.
• W2906768191 modified "2023-10-01" @default.
• W2906768191 title "Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster" @default.
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• W2906768191 doi "https://doi.org/10.1371/journal.pgen.1007886" @default.
• W2906768191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6336347" @default.
• W2906768191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30615609" @default.
• W2906768191 hasPublicationYear "2019" @default.
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