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- W2906876006 abstract "Although repetitive patterns of antigens are crucial for certain immune responses, an understanding of how antibodies bind and dynamically interact with various spatial arrangements of molecules is lacking. Hence, we introduced a new method in which molecularly precise nanoscale patterns of antigens are displayed using DNA origami and immobilized in a surface plasmon resonance set-up. Using antibodies with identical antigen-binding domains, we found that all the subclasses and isotypes studied bind bivalently to two antigens separated at distances that range from 3 to 17 nm. The binding affinities of these antibodies change with the antigen distances, with a distinct preference for antigens separated by approximately 16 nm, and considerable differences in spatial tolerance exist between IgM and IgG and between low- and high-affinity antibodies. The ordered display of antigen patterns on DNA origami platforms combined with surface plasmon resonance chips allows the investigation of the affinity and kinetics of the antigen–antibody bivalent binding in relation to the antigen distance and antibody flexibility." @default.
- W2906876006 created "2019-01-11" @default.
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- W2906876006 date "2019-01-14" @default.
- W2906876006 modified "2023-10-12" @default.
- W2906876006 title "Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies" @default.
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- W2906876006 doi "https://doi.org/10.1038/s41565-018-0336-3" @default.
- W2906876006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6420075" @default.
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