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• W2906976271 abstract "We describe a simple method for the synthesis of modified dinucleosides containing pyrimidine nucleoside analogues (2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine). Six different dimers with a 1,2,3-triazole linkage were obtained by azide-alkyne 1,3-dipolar cycloaddition (click reaction), starting from propargylated 2'-deoxyuridine and 5'-azido-nucleoside derivatives. Their cytotoxic activity was tested in five human cancer cell lines: cervical (HeLa), high grade gliomas (U-118 MG, U-87 MG, T98G), liver (HepG2), and normal human fibroblast cell line (MRC-5) using the sulforhodamine B (SRB) assay. The experiment showed that the obtained dimers with a 1,2,3-triazole moiety were very stable compounds, also in the physiological-like media, and had no anticancer activity." @default.
• W2906976271 created "2019-01-11" @default.
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• W2906976271 date "2018-12-27" @default.
• W2906976271 modified "2023-10-16" @default.
• W2906976271 title "Synthesis and biological assay of new 2’-deoxyuridine dimers containing a 1,2,3-triazole linker. Part I" @default.
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• W2906976271 doi "https://doi.org/10.1080/15257770.2018.1514122" @default.
• W2906976271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30588866" @default.
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