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- W2906981381 endingPage "167" @default.
- W2906981381 startingPage "151" @default.
- W2906981381 abstract "Introduction: Small cell lung cancer (SCLC) is a tumor with a poor prognosis, often diagnosed in an advanced stage. Despite aggressive treatment of early and locally advanced disease, SCLC often relapses. First line chemotherapy provides good response rates in advanced disease, but progression free and overall survival are limited. New drugs such as some targeted therapies and immune therapies are promising in SCLC.Areas covered: In this review, we discuss the preclinical rationale and trial data for targeted therapies and immune therapies in SCLC, with a specific focus on clinical trials.Expert commentary: Lack of identification of clear prognostic and predictive biomarkers has limited the advances in treatment efficacy. This has most likely been the main cause of failure for compounds tested so far. Due to the highly mutational profile and the rapid growth pattern of SCLC, immunotherapy combined with chemotherapy seems the most promising treatment option. Concerning targeted agents, achievements made so far are small, but DLL3-antibodies or combinations of PARPi and immunotherapy could be very promising. These promising strategies also need testing in limited disease." @default.
- W2906981381 created "2019-01-11" @default.
- W2906981381 creator A5001400077 @default.
- W2906981381 creator A5034267169 @default.
- W2906981381 creator A5046728958 @default.
- W2906981381 date "2018-12-28" @default.
- W2906981381 modified "2023-09-30" @default.
- W2906981381 title "Prospects of targeted and immune therapies in SCLC" @default.
- W2906981381 cites W130099911 @default.
- W2906981381 cites W1486001319 @default.
- W2906981381 cites W1541747338 @default.
- W2906981381 cites W1733892693 @default.
- W2906981381 cites W1757407923 @default.
- W2906981381 cites W1822869875 @default.
- W2906981381 cites W1903523058 @default.
- W2906981381 cites W1910892799 @default.
- W2906981381 cites W1923410233 @default.
- W2906981381 cites W1968293348 @default.
- W2906981381 cites W1968425173 @default.
- W2906981381 cites W1971264126 @default.
- W2906981381 cites W1971525245 @default.
- W2906981381 cites W1979840121 @default.
- W2906981381 cites W1985849470 @default.
- W2906981381 cites W1992552017 @default.
- W2906981381 cites W1996506613 @default.
- W2906981381 cites W1996628115 @default.
- W2906981381 cites W2003665515 @default.
- W2906981381 cites W2012026523 @default.
- W2906981381 cites W2015690088 @default.
- W2906981381 cites W2017296624 @default.
- W2906981381 cites W2019708706 @default.
- W2906981381 cites W2021276286 @default.
- W2906981381 cites W2023171799 @default.
- W2906981381 cites W2034269086 @default.
- W2906981381 cites W2040350406 @default.
- W2906981381 cites W2044905105 @default.
- W2906981381 cites W2046054013 @default.
- W2906981381 cites W2048011937 @default.
- W2906981381 cites W2049163106 @default.
- W2906981381 cites W2057235806 @default.
- W2906981381 cites W2063571428 @default.
- W2906981381 cites W2064514943 @default.
- W2906981381 cites W2069091742 @default.
- W2906981381 cites W2070608696 @default.
- W2906981381 cites W2070965927 @default.
- W2906981381 cites W2071596420 @default.
- W2906981381 cites W2073031201 @default.
- W2906981381 cites W2080259626 @default.
- W2906981381 cites W2082484803 @default.
- W2906981381 cites W2083749837 @default.
- W2906981381 cites W2083904374 @default.
- W2906981381 cites W2084117853 @default.
- W2906981381 cites W2090674284 @default.
- W2906981381 cites W2097457793 @default.
- W2906981381 cites W2098161852 @default.
- W2906981381 cites W2099467735 @default.
- W2906981381 cites W2101156795 @default.
- W2906981381 cites W2101615610 @default.
- W2906981381 cites W2104347254 @default.
- W2906981381 cites W2108348820 @default.
- W2906981381 cites W2108543032 @default.
- W2906981381 cites W2108927999 @default.
- W2906981381 cites W2110530327 @default.
- W2906981381 cites W2115891953 @default.
- W2906981381 cites W2123589978 @default.
- W2906981381 cites W2124473529 @default.
- W2906981381 cites W2125065061 @default.
- W2906981381 cites W2126666513 @default.
- W2906981381 cites W2129638180 @default.
- W2906981381 cites W2132028465 @default.
- W2906981381 cites W2132556766 @default.
- W2906981381 cites W2133006389 @default.
- W2906981381 cites W2136290128 @default.
- W2906981381 cites W2140487914 @default.
- W2906981381 cites W2142055223 @default.
- W2906981381 cites W2143996748 @default.
- W2906981381 cites W2145708352 @default.
- W2906981381 cites W2152061559 @default.
- W2906981381 cites W2152474505 @default.
- W2906981381 cites W2152497936 @default.
- W2906981381 cites W2155851270 @default.
- W2906981381 cites W2156353875 @default.
- W2906981381 cites W2156537375 @default.
- W2906981381 cites W2158127925 @default.
- W2906981381 cites W2165132221 @default.
- W2906981381 cites W2165429962 @default.
- W2906981381 cites W2166392962 @default.
- W2906981381 cites W2169848988 @default.
- W2906981381 cites W2170984340 @default.
- W2906981381 cites W2198093519 @default.
- W2906981381 cites W2221837786 @default.
- W2906981381 cites W2264814212 @default.
- W2906981381 cites W2267602746 @default.
- W2906981381 cites W2271351171 @default.
- W2906981381 cites W2275501998 @default.
- W2906981381 cites W2280957887 @default.
- W2906981381 cites W2317040753 @default.
- W2906981381 cites W2334091744 @default.