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- W2906990235 abstract "Primary testicular lymphoma (PTL) is a form of extra-nodal lymphoma originating from the testicles. Currently, positron emission tomography (PET) with glucose analogue 18F-fluorodeoxyglucose (18F-FDG) is the most popular and widely used modality for evaluating tumor metabolism, and PTL usually displays increased 18F-FDG uptake. Despite the rapid increase in clinical applications of FDG PET/ computed tomography (CT), its role in PTL has neither been clearly defined nor reviewed systematically. This study reviews the usefulness and limitation of FDG PET/CT in the diagnosis and treatment of PTL.This study included 12 patients with PTL between 2004 and 2015. We retrospectively examined PET/CT results along with patient outcome. The maximum standardized uptake value (SUVmax) was calculated.The mean overall survival (OS) and disease-free survival (DFS) was 44.5 months and 35.5 months, respectively. The mean SUVmax was identified as 18.5 in recurrent/metastatic group. The 1-year and 3-year OS was 94% and 69%, while the 1-year and 2-year DFS was 93.5% and 56%, respectively.FDG PET/CT is very helpful in both staging and evaluating treatment response. Although it is not a perfect tool in the initial diagnosis, it might aid in the differential diagnosis of challenging testicular tumors. Pre-treatment and post-treatment FDG uptake values may also have a prognostic value in patients with PTL.Amaç: Primer testis lenfoması (PTL) testis kaynaklı bir ekstranodal lenfomadır. 18F-florodeoksiglukoz (18F-FDG) pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) tümör metabolizmasını değerlendirmede yaygın olarak kullanılmaktadır ve PTL yüksek FDG tutulumu gösterir. FDG PET/BT’nin klinik uygulamalarının gün geçtikçe artmasına rağmen, PTL’deki rolü tam olarak tanımlanmamış ve sistematize edilmemiştir. Bu çalışma FDG PET/BT’nin PTL tanı ve tedavisindeki yararlılık ve kısıtlamalarını araştırmaktadır. Yöntem: Çalışma 2004-2015 yılları arasında 12 PTL hastasını içermektedir. Olguların geriye dönük olarak FDG PET/BT sonuçları ve gidişatları incelenmiştir. Maksimum standart tutulum değeri (SUVmaks) hesaplandı. Bulgular: Ortalama toplam sağkalım (OS) ve hastalıksız sağkalım (DFS) sırasıyla 44,5 ay ve 35,5 ay idi. Ortalama SUVmaks rekürrent/metastatik grupta 18,5 idi. OS 1. yılda %94, 3. yılda %69; DFS 1. yılda %93,5, 2. yılda %56 idi. Sonuç: FDG PET/BT evreleme ve tedaviye yanıt takibinde çok faydalıdır. Testis tümörlerinin ayırıcı tanısının zor olduğu olgularda yararlı olabilir. Fakat ilk tanıda iyi bir yöntem değildir. Tedavi öncesi veya sonrası FDG tutulum değerleri prognostik bir önem taşıyabilir." @default.
- W2906990235 created "2019-01-11" @default.
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- W2906990235 date "2018-06-08" @default.
- W2906990235 modified "2023-10-02" @default.
- W2906990235 title "Utility of FDG PET/CT in the Management of Primary Testicular Lymphoma" @default.
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- W2906990235 doi "https://doi.org/10.4274/mirt.14227" @default.
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