Matches in SemOpenAlex for { <https://semopenalex.org/work/W2906999196> ?p ?o ?g. }
- W2906999196 endingPage "99" @default.
- W2906999196 startingPage "86" @default.
- W2906999196 abstract "Copper plays an important role in tumor growth and metastasis. Copper chelation has been confirmed to be an effective strategy for breast cancer therapy through antiangiogenesis. In this work, a copper chelating coil-comb block copolymer RGD-PEG-b-PGA-g-(TETA-DTC-PHis) (RPTDH) was synthesized and used to prepare nanoparticles for loading resiquimod (R848), a TLR7 and TLR8 agonist, thus to combine antiangiogenesis and immune activation to treat breast cancer. RPTDH has strong copper-chelating ability and could self-assemble to form spherical nanoparticles with significant pH-sensitivity. R848 was efficiently loaded into RPTDH nanoparticles and exhibited greatly accelerated releases in weakly acid media simulating tumor microenvironment. RPTDH/R848 nanoparticles significantly inhibited the mobility, invasion and vascular tube formation of HUVECs via copper chelation, demonstrating their strong antiangiogenic activity in vitro. Furthermore, RPTDH/R848 nanoparticles remarkably induced the maturation and activation of human plasmacytoid dendritic CAL-1 cells, indicating their immune-activation ability. In breast tumor-bearing mice, RPTDH/R848 nanoparticles displayed excellent targeting ability for both primary breast tumor and lung metastases, and furthermore dramatically suppressed tumor growth and metastasis through copper deficiency-triggered antiangiogenesis and R848-induced immune activation. In summary, RPTDH/R848 nanoparticles can be used as an therapeutic agent against metastatic breast cancer through combining antiangiogenesis and immune activation." @default.
- W2906999196 created "2019-01-11" @default.
- W2906999196 creator A5000835804 @default.
- W2906999196 creator A5021547555 @default.
- W2906999196 creator A5024403238 @default.
- W2906999196 creator A5039728001 @default.
- W2906999196 creator A5054418515 @default.
- W2906999196 creator A5054464310 @default.
- W2906999196 creator A5059515600 @default.
- W2906999196 creator A5069098060 @default.
- W2906999196 creator A5069429997 @default.
- W2906999196 date "2019-03-01" @default.
- W2906999196 modified "2023-10-16" @default.
- W2906999196 title "Multifunctional nanoparticles based on a polymeric copper chelator for combination treatment of metastatic breast cancer" @default.
- W2906999196 cites W1876035649 @default.
- W2906999196 cites W1922412259 @default.
- W2906999196 cites W1971764264 @default.
- W2906999196 cites W1972776583 @default.
- W2906999196 cites W1978398769 @default.
- W2906999196 cites W1979335059 @default.
- W2906999196 cites W1991236592 @default.
- W2906999196 cites W1993053769 @default.
- W2906999196 cites W2003705772 @default.
- W2906999196 cites W2012613362 @default.
- W2906999196 cites W2012899108 @default.
- W2906999196 cites W2032092238 @default.
- W2906999196 cites W2045449124 @default.
- W2906999196 cites W2045616069 @default.
- W2906999196 cites W2059009998 @default.
- W2906999196 cites W2065203610 @default.
- W2906999196 cites W2065771556 @default.
- W2906999196 cites W2080493328 @default.
- W2906999196 cites W2082629296 @default.
- W2906999196 cites W2084276469 @default.
- W2906999196 cites W2090760425 @default.
- W2906999196 cites W2097255712 @default.
- W2906999196 cites W2099090110 @default.
- W2906999196 cites W2101902354 @default.
- W2906999196 cites W2110772556 @default.
- W2906999196 cites W2112648444 @default.
- W2906999196 cites W2118775158 @default.
- W2906999196 cites W2127714324 @default.
- W2906999196 cites W2157567077 @default.
- W2906999196 cites W2159672615 @default.
- W2906999196 cites W2162259135 @default.
- W2906999196 cites W2164363791 @default.
- W2906999196 cites W2168162034 @default.
- W2906999196 cites W2193666963 @default.
- W2906999196 cites W2296767826 @default.
- W2906999196 cites W2320686523 @default.
- W2906999196 cites W2409932367 @default.
- W2906999196 cites W2509518005 @default.
- W2906999196 cites W2550858844 @default.
- W2906999196 cites W2597795073 @default.
- W2906999196 cites W2606489331 @default.
- W2906999196 cites W2767942587 @default.
- W2906999196 cites W2807537271 @default.
- W2906999196 doi "https://doi.org/10.1016/j.biomaterials.2019.01.007" @default.
- W2906999196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30623789" @default.
- W2906999196 hasPublicationYear "2019" @default.
- W2906999196 type Work @default.
- W2906999196 sameAs 2906999196 @default.
- W2906999196 citedByCount "70" @default.
- W2906999196 countsByYear W29069991962019 @default.
- W2906999196 countsByYear W29069991962020 @default.
- W2906999196 countsByYear W29069991962021 @default.
- W2906999196 countsByYear W29069991962022 @default.
- W2906999196 countsByYear W29069991962023 @default.
- W2906999196 crossrefType "journal-article" @default.
- W2906999196 hasAuthorship W2906999196A5000835804 @default.
- W2906999196 hasAuthorship W2906999196A5021547555 @default.
- W2906999196 hasAuthorship W2906999196A5024403238 @default.
- W2906999196 hasAuthorship W2906999196A5039728001 @default.
- W2906999196 hasAuthorship W2906999196A5054418515 @default.
- W2906999196 hasAuthorship W2906999196A5054464310 @default.
- W2906999196 hasAuthorship W2906999196A5059515600 @default.
- W2906999196 hasAuthorship W2906999196A5069098060 @default.
- W2906999196 hasAuthorship W2906999196A5069429997 @default.
- W2906999196 hasConcept C121608353 @default.
- W2906999196 hasConcept C126322002 @default.
- W2906999196 hasConcept C155672457 @default.
- W2906999196 hasConcept C171250308 @default.
- W2906999196 hasConcept C191897082 @default.
- W2906999196 hasConcept C192562407 @default.
- W2906999196 hasConcept C197404232 @default.
- W2906999196 hasConcept C203014093 @default.
- W2906999196 hasConcept C2775930923 @default.
- W2906999196 hasConcept C2776107976 @default.
- W2906999196 hasConcept C2779013556 @default.
- W2906999196 hasConcept C502942594 @default.
- W2906999196 hasConcept C530470458 @default.
- W2906999196 hasConcept C71924100 @default.
- W2906999196 hasConcept C8891405 @default.
- W2906999196 hasConceptScore W2906999196C121608353 @default.
- W2906999196 hasConceptScore W2906999196C126322002 @default.
- W2906999196 hasConceptScore W2906999196C155672457 @default.
- W2906999196 hasConceptScore W2906999196C171250308 @default.
- W2906999196 hasConceptScore W2906999196C191897082 @default.