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• W2907013312 abstract "Optical imaging is one of the most common, low-cost imaging tools used for investigating the tumor biological behavior in vivo. This study explores the feasibility and sensitivity of a near infrared fluorescent protein mKate2 for a long-term non-invasive tumor imaging in BALB/c nude mice, by using a low-power optical imaging system.In this study, breast cancer cell line MDA-MB-435s expressing mKate2 and MDA-MB-231 expressing a dual reporter gene firefly luciferase (fLuc)-GFP were used as cell models. Tumor cells were implanted in different animal body compartments including subcutaneous, abdominal and deep tissue area and closely monitored in real-time. A simple and low-power optical imaging system was set up to image both fluorescence and bioluminescence in live animals.The presence of malignant tissue was further confirmed by histopathological assay. Considering its lower exposure time and no need of substrate injection, mKate2 is considered a superior choice for subcutaneous imaging compared with fLuc. On the contrary, fLuc has shown to be a better option when monitoring the tumor in a diffusive area such as abdominal cavity. Furthermore, both reporter genes have shown good stability and sensitivity for deep tissue imaging, i.e. tumor within the liver. In addition, fLuc has shown to be an excellent method for detecting tumor cells in the lung.The combination of mKate2 and fLuc offers a superior choice for long-term non-invasive real-time investigation of tumor biological behavior in vivo." @default.
• W2907013312 created "2019-01-11" @default.
• W2907013312 creator A5005718615 @default.
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• W2907013312 creator A5082320568 @default.
• W2907013312 date "2018-12-01" @default.
• W2907013312 modified "2023-10-12" @default.
• W2907013312 title "In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system" @default.
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• W2907013312 doi "https://doi.org/10.1186/s12938-018-0615-0" @default.
• W2907013312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6310933" @default.
• W2907013312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30594200" @default.
• W2907013312 hasPublicationYear "2018" @default.
• W2907013312 type Work @default.
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