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- W2907029591 abstract "Introduction: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF) is the most common cause of PH worldwide and has no proven effective therapies. Our recent data show that SIRT3 activation levels are specifically decreased in skeletal muscle, concomitant with robust increase of pulmonary pressures and vascular remodeling. Restoration of SIRT3 in skeletal muscle with nitrite and metformin therapies improve metabolic syndrome and reduces disease phenotypes. However, it is unknown whether SIRT3 activation in skeletal muscle is critical for the beneficial effects of nitrite and metformin on both metabolic abnormalities and cardiopulmonary defects underlying PH-HFpEF. Methods and Results: Using skeletal muscle-specific SIRT3 KO (SIRT3skm-/-) mice with 16 weeks of high-fat feeding (HFD, 60% fat in Kcal), which induces a PH-HFpEF phenotype in mice, in the presence or absence of nitrite (100 mg/L) and metformin (300 mg/kg), we examined the impact of skeletal muscle SIR..." @default.
- W2907029591 created "2019-01-11" @default.
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- W2907029591 date "2017-11-14" @default.
- W2907029591 modified "2023-09-23" @default.
- W2907029591 title "Abstract 18008: Skeletal Muscle SIRT3 is Required for Nitrite- and Metformin-Mediated Reduction of PH-HFpEF" @default.
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